未分化结缔组织病合并妊娠患者134例妊娠结局分析  

Analysis of pregnancy outcomes in 134 patients with undifferentiated connective tissue disease

作　　者：丁菱[1] 何善智[1] 邹婵娟[1] 王明霞[1] 王敏[1] 颜丝语 曾涵将 DING Ling;HE Shan-zhi;ZHOU Chan-juan;WANG Ming-xia;WANG Min;YAN Si-yu;ZENG Han-jiang(Department of Rheumatic Immunology,Zhongshan People′s Hospital,Zhongshan 528400,Guangdong,China)

机构地区：[1]中山市人民医院风湿免疫科,广东中山528400

出　　处：《广东医学》2024年第1期29-34,共6页Guangdong Medical Journal

摘　　要：目的探讨未分化结缔组织病(undifferentiated connective tissue disease,UCTD)合并妊娠患者流产或早产结局的影响因素。方法回顾性分析2017年1月1日至2021年12月31日收治的134例UCTD合并妊娠患者的临床资料,分为流产/早产组(n=38)和足月产组(n=96),通过比较两组患者的临床资料、用药情况和实验室检查结果,分析UCTD合并妊娠患者流产或早产的危险因素。结果Logistic单因素分析结果提示:使用羟氯喹或使用小剂量激素预测患者发生流产及早产风险的OR值分别为0.30(95%CI:0.13~0.67)和0.43(95%CI:0.20~0.92)。Logistic多因素分析结果提示:使用羟氯喹是患者发生流产或早产结局的独立预测因素(OR=0.297,95%CI:0.134~0.658),也就意味着在其他影响因素均衡的条件下,随着羟氯喹的使用,患者发生流产或早产结局的风险也在减少,使用羟氯喹是UCTD患者流产或早产的保护因素。结论小剂量激素使用、羟氯喹使用可以降低UCTD妊娠患者的流产或早产风险。Objective To investigate the influence factors of premature birth or abortion in pregnant patients with undifferentiated connective tissue disease(UCTD).Methods Data of 134 pregnant patients with UCTD from January 1st,2017 to December 31st,2021 were retrospectively analyzed and were divided into premature birth/abortion group(n=38)and mature birth group(n=96).Risk factors of premature birth or abortion were investigated by comparing the clinical records,medications and clinical examinations between these two groups.Results Univariate logistic analysis showed that the odd ratio(OR)of using hydroxychloroquine or using low-dose glucocorticoid to predict premature birth or abortion in pregnant patients with UCTD was 0.30(95%CI:0.13-0.67)and 0.43(95%CI:0.20-0.92),respectively,suggesting that using hydroxychloroquine and low-dose glucocorticoid may reduce the risk of premature birth or abortion.Multivariate logistic analysis showed that using hydroxychloroquine was an independent protective factor of abortion or preterm birth(OR=0.297,95%CI:0.134-0.658).Conclusion Using hydroxychloroquine and low-dose glucocorticoid may reduce the risk of abortion or premature birth in pregnant patients with UCTD.

关 键 词：未分化结缔组织病 妊娠 流产 早产 

分 类 号：R593.2[医药卫生—内科学] R714.25[医药卫生—临床医学]