基于数据挖掘的中药临床新用特点分析  

Clinical Features of Repurposed Chinese Medicine Based on Data Mining

作　　者：张锦瑞 惠香香 苗明三[1] ZHANG Jinrui;HUI Xiangxiang;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学,郑州450046

出　　处：《中药药理与临床》2023年第12期112-117,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局标准化项目(编号:GZY-FJS-2020-219);国家国际合作基地项目(编号:2016-65);河南省药品监督管理局科技计划项目(编号:2020DB050-55)。

摘　　要：目的:对中药临床新用特点进行总结和分析,为“理论-临床-新药”的发展模式提供数据支撑及参考。方法:通过查阅中国知网、万方数据、维普中文期刊服务平台和中国生物医学文献数据库中关于中药临床新用的近十年文献,将筛选后相关方药的种类、应用方式、剂型、频数、主治类型、等信息进行统计分析,并运用IBM SPSS Statistics 25.0、Clementine 12.0等数据处理软件,以主治类型中频数最高的肝胆脾胃(消化)系疾病药物为例,得其高频药物、关联规则及聚类结果,总结肝脾同治的新药运用规律,分析中药临床新用的整体进展状况。结果:共查阅到医案863则,古方新用712则,中药新用108则,中成药新用43则。肝胆脾胃(消化)系疾病新用医案涵盖218味中药,高频中药24味;核心药对10个,聚类5组。结论:中药临床新用的应用方式以内服为主;剂型以传统剂型之汤剂为主,其次为丸剂、散剂;高频方药有补阳还五汤、血府逐瘀汤、六神丸、四物汤、六味地黄丸、补中益气汤6种,补中益气汤和六神丸包含的临床病证应用频数最高;最常见于肝胆脾胃(消化)系疾病和脑(神经)系疾病的治疗中。肝脾同治用药次数最多的是甘草、当归、白芍、等;药性以寒性、温性为主,药味以甘、苦、辛居多,归经以肝经、胃经、肺经和脾经为主;补虚为重要治法。Objective:To summarize and analyze clinical features of repurposed Chinese medicine to provide data support and references for the development model of“theory-clinical practice-new drugs”.Methods:CNKI,Wanfang Data,VIP,and SinoMed were searched for the research articles on clinical repurposing of Chinese medicine published in the recent 10 years.After screening,statistical analysis was carried out on the types,application methods,dosage forms,frequencies,and indications of relevant prescriptions,and data were processed with IBM SPSS Statistics 25.0 and Clementine 12.0.With the drugs indicated for the liver,gallbladder,spleen,and stomach(digestive system)diseases with the highest frequency in indications as an example,the high-frequency drugs and the results of association rules and clustering analysis were obtained.The application regularity of new drugs for the simultaneous treatment of Gan(肝)and Pi(脾)was summarized and the overall progress in clinical repurposing of Chinese medicine was analyzed.Results:After screening,863 medical records,712 repurposed classic prescriptions,108 repurposed Chinese medicines,and 43 repurposed Chinese patent medicines were obtained.A total of 218 repurposed Chinese medicines indicated for liver,gallbladder,spleen,and stomach(digestive system)diseases were involved in medical records,with 24 high-frequency ones,10 core medicinal combinations,and 5 categories clustered.Conclusion:The clinical application of repurposed Chinese medicine was mainly oral administration.The dosage form was mainly decoction,followed by pills and powder.High-frequency prescriptions included Buyang Huanwu Decoction(补阳还五汤),Xuefu Zhuyu Decoction(血府逐瘀汤),Liushen Pills(六神丸),Siwu Decoction(四物汤),Liuwei Dihuang Pills(六味地黄丸),and Buzhong Yiqi Decoction(补中益气汤).Buzhong Yiqi Decoction and Liushen Pills had the highest frequencies of clinical application for clinical symptoms.The indications were dominated by liver,gallbladder,spleen,and stomach(digestive system

关 键 词：中药 中成药 古方新用 肝脾同治 特点分析 数据挖掘 

分 类 号：R28[医药卫生—中药学]