非编码RNA在痛风性关节炎中的研究进展  

Research Progress of Non-Coding RNA in Gouty Arthritis

作　　者：于栋华[1] 王晓菲 刘婷婷 王宇[1] 刘树民[1] 于纯淼[2] YU Donghua;WANG Xiaofei;LIU Tingting;WANG Yu;LIU Shumin;YU Chunmiao(Institute of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040;College of Pharmacy,Heilongjiang University of Chinese Medicine,Harbin 150040)

机构地区：[1]黑龙江中医药大学中医药研究院,哈尔滨150040 [2]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《中药药理与临床》2023年第12期123-128,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金(青年)(编号:81803871);国家自然科学基金(面上)(编号:82074149);博士后科研启动金(编号:LBH-Q18121)。

摘　　要：痛风是一种与体内嘌呤代谢紊乱和(或)影响尿酸排泄的高尿酸血症直接相关的代谢性疾病。近年来,随着生活习惯、饮食结构的改变,痛风患者日趋增多,临床发病率也逐年升高。随着二代测序的深入发展,非编码RNA在痛风疾病中发挥重要作用。非编码RNA(Non-coding RNA)是一类含量丰富且功能多样而不进行蛋白质翻译的RNA,根据核苷酸长度分为,长链非编码RNA(long non-coding RNA,lncRNA)及短链非编码RNA。有研究显示非编码RNA在痛风发病进展及管理中发挥重要作用。因此,本文就非编码RNA的研究进展进行综述,以期探讨非编码RNA与痛风及其发病机制之间的作用关系。Gout is a metabolic disease directly related to hyperuricemia caused by disorder of purine metabolism and/or decreased excretion of uric acid.In recent years,with changes in living habits and dietary structure,the number of patients with gout has increased day by day,and the clinical incidence has also increased year by year.With the in-depth development of next-generation sequencing,non-coding RNA plays an important role in gout disease.Non-coding RNA is a type of RNA that is rich in content and has multiple functions without translating proteins.According to the length of nucleotides,it is divided into long non-coding RNA(IncRNA)and short non-coding stranded RNA.Studies have shown that non-coding RNA is essential for the progression and management of gout.Therefore,this article reviewed the research progress of non-coding RNA in order to explore the relationship between non-coding RNA and gout and its pathogenesis.

关 键 词：痛风 代谢性疾病 非编码RNA 痛风性关节炎 

分 类 号：R589.7[医药卫生—内分泌]