结扎不同左冠状动脉分支对大鼠左室结构和功能的影响  

Effects of ligation of different branches of Left coronary artery on left ventricular structure and function in rats

作　　者：崔岩芳 万伟平 黄春燕 韩超 CUI Yanfang;WAN Weiping;HUANG Chunyan;HAN Chao(Department of Ultrasound,Yantaishan Hospital,Yantai,Shandong 264003,China)

机构地区：[1]烟台山医院超声科,山东烟台264003

出　　处：《影像研究与医学应用》2024年第1期21-23,共3页Journal of Imaging Research and Medical Applications

基　　金：烟台市科技计划项目(2019MSGY137)。

摘　　要：目的:基于大鼠与人体冠状动脉解剖结构的差异,通过超声心动图探讨结扎大鼠前降支与回旋支对左室结构及射血分数的影响。方法:24例Wistar大鼠按月龄配伍后随机分为前降支(LAD)组和回旋支(LCX)组,超声心动图观察各组左房内径、左室内径及容积、左室射血分数等。结果:两组术后与术前相比,心率、左房内径、左室舒张末期内径等增加(P<0.05),左室射血分数减低(P<0.05),差异有统计学意义,而主动脉内径前后相比无显著性差异(P>0.05)。进一步分析发现LCX组操作后与术前相比左房内径、左室舒张末期内径等增加,左室射血分数下降,同样差异有统计学意义(P<0.05),相比LAD组前者变化差异无统计学意义(P<0.05)。结论:结扎大鼠回旋支同样能使得大鼠左房室扩大,并影响左室射血功能,只是后者相比结扎前降支影响小。Objective Based on the differences of coronary artery anatomy between rat and human,echocardiography was used to investigate the effects of ligation of left anterior descending artery and left circumflex artery on left ventricular structure and ejection fraction.Methods 24 Wistar rats were randomly divided into left anterior descending artery(LAD) group and left circumflex artery(LCX) group according to age.Left atrial diameter,left ventricular diameter and volume,left ventricular ejection fraction and so on were observed by echocardiography.Results Compared with the two groups,the heart rate,left atrial diameter and left ventricular end-diastolic diameter increased after surgery(P<0.05),and left ventricul ar ejection fraction decreased(P<0.05),with statistical differences,but there was no significant difference in aortic diameter before and after surgery(P>0.05).Further analysis showed that the left atrial diaameter and left ventricular end-diastolic diameter increased and left ventricular ejection fraction decreased in LCX group after operation compared with that before operation(P<0.05),but there was no statistical difference in the former compared with LAD group(P<0.05).Conclusion Ligation of the circumflex branch can also enlarge the left atrioventricular and affect the left ventricular ejection function,but the latter has less effect than the descending branch before ligation.

关 键 词：心脏 急性缺血模型 超声心动图 大鼠 

分 类 号：R445.1[医药卫生—影像医学与核医学]