特发性中枢性性早熟和快速进展型早发育儿童的体质研究  

Constitution of children with idiopathic central precocious puberty and rapidly progressive early development

作　　者：杨楚文 赵鋆[1] 芦小叶 宋勤丽 周芳源 Yang Chuwen;Zhao Jun;Lu Xiaoye;Song Qinli;Zhou Fangyuan(Department of Paediatrics,the Affiliated Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院儿科,上海201203

出　　处：《国际中医中药杂志》2024年第1期24-29,共6页International Journal of Traditional Chinese Medicine

基　　金：东部中西医结合儿科协同诊疗网络建设项目(ZY〔2021-2023〕-0206-02)。

摘　　要：目的探讨特发性中枢性性早熟(ICPP)与快速进展型早发育(EFP)儿童中医证型、中医体质、临床症状的关系,为早期干预及辨证论治提供依据。方法本研究为横断面研究和回顾性研究。收集2022年7-8月上海中医药大学附属曙光医院儿科内分泌门诊200例ICPP与EFP患儿的基本信息、临床证候及中医体质的相关数据,分析ICPP与EFP患儿中医体质分布、辨证分型及临床症状的关联性。结果①EFP患儿BMI、年龄高于ICPP患儿(P<0.05),性别比较,差异无统计学意义(P>0.05)。②ICPP与EFP患儿中医证型以肝郁化火证居多,分别为59.15%(42/71)、46.51%(60/129);体质以气郁质居多,分别为35.21%(25/71)、36.43%(47/129),但ICPP与EFP患儿总体中医证型、体质比较,差异无统计学意义(P>0.05)。③200例ICPP与EFP患儿的中医证型与体质相关,其中阴虚火旺证与阴虚质,肝郁化火证与气郁质,痰湿壅滞证与痰湿质、阳虚质显著相关(P<0.01)。④200例ICPP与EFP患儿中,女童多于男童,男童BMI高于女童,痰湿壅滞证ICPP与EFP患儿BMI高于其他证型(P<0.01)。ICPP与EFP患儿不同性别的中医证型比较,差异无统计学意义(P>0.05)。临床症状以乳房胀痛为主,为22.19%(69/311)。结论EFP患儿BMI、年龄高于ICPP患儿;性别、中医证型及体质分布无明显差异,但ICPP与EFP患儿的中医证候类型与体质类型间有相关性。Objective Exploratory study on the relationship between TCM syndrome types,TCM constitution and clinical symptoms of idiopathic central precocious puberty children and rapidly progressive early development children in Shanghai,so as to provide a basis for early intervention and syndrome differentiation and treatment.Methods A cross-sectional study and retrospectively enrolled.Through questionnaire survey,the basic information,clinical symptoms and TCM constitution of children diagnosed with idiopathic central precocious puberty and rapidly progressive early development were collected from the Pediatric Endocrinology Clinic of Affiliated Shuguang Hospital of Shanghai University of Traditional Chinese Medicine from July to August 2022,and the correlation between the distribution,differentiation and clinical symptoms of TCM constitution in children with idiopathic central precocious puberty and children with rapidly progressive precocious puberty in Shanghai were explored through data analysis.Results①Fast progressive early development children with higher BMI and age than idiopathic central precocious puberty were statistically significant(P<0.05),and no significant difference in the sex composition ratio between the two groups.Among children with idiopathic central precocious puberty and children with rapid progressive early development,the proportion of liver depression fire syndrome was the highest,59.15%(42/71)and 46.51%(60/129)respectively,and the proportion of Qi depression was the highest,35.21%(25/71)and 36.43%(47/129)respectively.However,there was no significant difference in the TCM syndrome types and physical distribution of the two groups.③The TCM syndrome types of 200 precocious children weres correlated with physical distribution,among which Yin deficiency fire flourishing syndrome was significantly associated with Yin deficiency,liver stagnation fire syndrome was significantly correlated with qi depression,and phlegm dampness obstruction syndrome was significantly correlated with phlegm dampness

关 键 词：青春期 早熟 特发性中枢性性早熟 快速进展型早发育 中医体质 临床证候 

分 类 号：R725.8[医药卫生—儿科]