菊钩逍遥散对耳石症手法复位后肝郁型残余头晕患者血浆ET-1、CGRP及NPY水平的影响  

Effect of Jugou Xiaoyao Powder on Plasma ET-1,CGRP and NPY Levels in Patients with Residual Dizziness Caused by Liver Depression after Manual Reduction of Otolithiasis

作　　者：徐红霞[1] 王庆全 盛国强[1] 邹广华[1] 汪常伟[1] Xu Hongxia;Wang Qingquan;Sheng Guoqiang;Zou Guanghua;Wang Changwei(The Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Xinjiang,Urumuqi 830000,China)

机构地区：[1]新疆医科大学附属中医医院,新疆乌鲁木齐830000

出　　处：《中国中医急症》2024年第1期119-122,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金面上项目(2022D01C539);新疆医科大学附属中医医院院级课题重点项目(ZYY2020ZD03)。

摘　　要：目的观察菊钩逍遥散治疗耳石症手法复位后肝郁型残余头晕(RD)的疗效,及对血浆中内皮素-1(ET-1)、降钙素基因相关肽(CGRP)及神经肽Y(NPY)水平的影响并探讨其作用机制。方法90例患者随机分成对照组、中药组和联合组3组各30例。对照组给予甲磺酸倍他司汀片口服,中药组给予菊钩逍遥散口服,联合组给予菊钩逍遥散和甲磺酸倍他司汀片口服。治疗2周后,观察各组的临床疗效、DHI评分、SAS评分和血浆中ET-1、CGRP及NPY的变化。结果联合组总有效率为93.33%,高于中药组的82.76%和对照组的66.67%(P<0.05)。3组治疗前DHI、SAS评分、ET-1、CGRP和NPY含量比较,差别均不大(均P>0.05)。3组治疗后DHI、SAS评分均较治疗前降低(均P<0.01),且中药组、联合组的DHI、SAS评分均低于对照组(均P<0.01),而中药组和联合组DHI、SAS评分比较差别均不大(P>0.05)。3组治疗后ET-1、NPY含量均较治疗前降低(均P<0.01);中药组、联合组ET-1、NPY含量均低于对照组(均P<0.01),中药组和联合组比较,差异无统计学意义(P>0.05)。3组治疗后CGRP含量均较治疗前升高(均P<0.01),且中药组、联合组CGRP含量均高于对照组,联合组CGRP含量高于中药组(均P<0.01)。治疗过程中对照组出现2例便秘,中药组出现1例胃部不适,联合组出现1例便秘,各组均未见其他明显不良反应。结论菊钩逍遥散治疗RD疗效确切,能够缓解焦虑而改善残余头晕,其作用机制可能与调节血浆中ET-1、CGRP及NPY的水平有关。Objective:To observe the efficacy of Jugou Xiaoyao Powder in treating residual dizziness(RD)caused by liver depression after manual reduction of otolithiasis,and its influence on plasma levels of endothelin-1(ET-1),calcitonin gene-related peptide(CGRP)and neuropeptide Y(NPY).Methods:A total of 90 patients with liver depression type RD were randomly divided into control group,Chinese medicine group and combined group,with 30 cases in each group.The control group took betahistine mesilate tablet orally,the Chinese medicine group took Jugou Xiaoyao Powder orally,and the combined group took Jugou Xiaoyao Powder and betahistine mesilate tablet orally.After 2 weeks of treatment,the clinical efficacy,DHI score,SAS score and the changes of ET-1,CGRP and NPY in plasma were observed.Results:The total effective rate of the combined group was 93.33%,which was higher than 82.76%of the Chinese medicine group and 66.67%of the control group(P<0.05).The DHI and SAS scores in the three groups were all lower than those before treatment(P<0.01),and the scores in the traditional Chinese medicine group and the combined group were lower than those in the control group(all P<0.01),while there was no significant difference between the traditional Chinese medicine group and the combined group(P>0.05).The contents of ET-1 and NPY in the three groups were lower than those before treatment(all P<0.01),and the contents of ET-1 and NPY in the traditional Chinese medicine group and the combined group were lower than those in the control group(all P<0.01),and there was no significant difference between the traditional Chinese medicine group and the combined group(P>0.05).After treatment,the CGRP content of the three groups was higher than that before treatment(all P<0.01),and the CGRP content of the traditional Chinese medicine group and the combined group was higher than that of the control group,and the CGRP content of the combined group was higher than that of the traditional Chinese medicine group(all P<0.01).During the treatment,there were

关 键 词：耳石症 菊钩逍遥散 手法复位 残余头晕 

分 类 号：R255.3[医药卫生—中医内科学]