槲皮素防治急性肝损伤作用机制的研究进展  

Research progress on mechanism of quercetin in prevention and treatment of acute liver injury

作　　者：张冬梅 杨强 刘敏 ZHANG Dong-mei;YANG Qiang;LIU Min(Department of Emergency,The People's Hospital of Dazu,Chongqing 402360,China;Department of Infection,The People's Hospital of Dazu,Chongqing 402360,China;Department of Stomatology,The People's Hospital of Dazu,Chongqing 402360,China)

机构地区：[1]重庆市大足区人民医院急诊科,重庆402360 [2]重庆市大足区人民医院感染科,重庆402360 [3]重庆市大足区人民医院口腔科,重庆402360

出　　处：《现代药物与临床》2023年第12期3166-3173,共8页Drugs & Clinic

基　　金：重庆市科卫联合医学科研项目(2018MSXM089)。

摘　　要：急性肝损伤是一种严重的疾病,其发病机制和影响因素多种多样,其中药物治疗是目前急性肝损伤的主要治疗方法。槲皮素为黄酮醇类化合物,可通过抗炎、抗氧化应激反应、抗肝纤维化、抗细胞凋亡、增强细胞自噬、抑制转运体NTCP的表达降低胆汁酸重吸收、调节肝脏脂质代谢,多途径减轻肝损伤,发挥肝保护作用。总结了槲皮素防治急性肝损伤的作用机制,为急性肝损伤治疗提供参考。Acute liver injury is a serious disease with diverse pathogenesis and influencing factors.Drug therapy is currently the main treatment method for acute liver injury.Quercetin is a flavonol,and can alleviate liver injury through multiple pathways and exert liver protective effects through anti-inflammatory,anti-oxidative stress,anti-liver fibrosis,anti-apoptosis,enhancing autophagy,inhibiting the expression of transporter NTCP to reduce bile acid reabsorption,regulating liver lipid metabolism.This article summarizes the mechanism of quercetin in prevention and treatment of acute liver injury,providing reference for the treatment of acute liver injury.

关 键 词：槲皮素 急性肝损伤 抗炎 抗氧化应激 抗肝纤维化 抗细胞凋亡 细胞自噬 肝脏脂质代谢 

分 类 号：R975[医药卫生—药品]