益气养阴活血化瘀方联合降糖补肾丸治疗糖尿病肾病疗效观察  

作　　者：张盼 

机构地区：[1]河南省商丘市中医院内分泌科,河南商丘476000

出　　处：《实用中医药杂志》2023年第12期2305-2307,共3页Journal of Practical Traditional Chinese Medicine

摘　　要：目的:观察益气养阴活血化瘀方联合降糖补肾丸治疗糖尿病肾病(Diabetic nephropathy,DN)的疗效。方法:84例用随机数字表法分为对照组和研究组各42例。两组用降糖补肾丸治疗,研究组用益气养阴活血化瘀方治疗。结果:总有效率研究组高于对照组(P<0.05),治疗8周后腰膝酸痛、疲倦乏力、面色晦暗、气短懒言等评分研究组低于对照组(P<0.05),治疗8周后Scr、BUN、24 h Upro水平研究组低于对照组(P<0.05),治疗8周后血清hs-CRP、TNF-α、ANGPTL4水平研究组低于对照组而CTRP3水平高于对照组(P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:益气养阴活血化瘀方联合降糖补肾丸治疗DN疗效较好,且安全。Objective:To observe the curative effect of Yiqi Yangyin Huoxue Huayu Decoction combined with Jiangtang Bushen Pills in the treatment of diabetic nephropathy(DN).Methods:Eighty-four cases were divided into the control group and the study group by random number table method,42 cases in each group.The two groups were treated with Jiangtang Bushen Pills,and the study group were treated with Yiqi Yangyin Huoxue Huayu Decoction.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).After 8 weeks of treatment,the scores of waist and knee pain,fatigue,dull complexion,shortness of breath and lazy words in the study group were lower than those in the control group(P<0.05).After 8 weeks of treatment,the levels of Scr,BUN and 24 h Upro in the study group were lower than those in the control group(P<0.05).After 8 weeks of treatment,the levels of serum hs-CRP,TNF-αand ANGPTL4 in the study group were lower than those in the control group,while the level of CTRP3 was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Yiqi Yangyin Huoxue Huayu Decoction combined with Jiangtang Bushen Pills is effective and safe in the treatment of DN.

关 键 词：糖尿病肾病 益气养阴活血化瘀方 降糖补肾丸 对照治疗观察 

分 类 号：R255.487.2[医药卫生—中医内科学]