九香虫水提取物中一对新颖Z/E异构化的吡啶季胺盐  

An unprecedented pair of Z/E isomeric pyridinium compound from the aqueous extract of Aspongopus chinensis Dallas

作　　者：王春江[1] 杨灿熙 任凌希 刘韶[2,3] 蒋跃平[2,3] WANG Chun-jiang;YANG Can-xi;REN Ling-xi;LIU Shao;JIANG Yue-ping(Department of Pharmacy,the Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008,China;Institute for Rational and Safe Medication Practices,National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China;College of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;School of Pharmaceutical Science,Jishou University,Jishou 416000,China)

机构地区：[1]中南大学湘雅三医院药学部,湖南长沙410013 [2]中南大学湘雅医院药学部,湖南长沙410008 [3]中南大学湘雅医院,国家老年疾病临床医学研究中心,湖南长沙410008 [4]中国药科大学药学院,江苏南京210009 [5]吉首大学药学院,湖南吉首416000

出　　处：《药学学报》2024年第1期166-169,共4页Acta Pharmaceutica Sinica

摘　　要：采用大孔吸附树脂、正相硅胶、反向半制备等色谱技术,从中药九香虫水提取中分离得到一对Z/E异构化吡啶季胺盐新颖碳骨架类化合物。通过核磁共振、红外、质谱等多种光谱技术鉴定了两个新化合物1和2的结构分别为(Z)-3-(but-1″-en-1″-yl)-1-(2?-hydroxyethyl)-4-propylpyridin-1-ium,命名为aspongopyridine A和(E)-3-(but-1″-en-1″-yl)-1-(2?-hydroxyethyl)-4-propylpyridin-1-ium,命名为aspongopyridine B。此外,还对化合物1和2的体外抗炎、抗肿瘤、乙酰胆碱酯酶抑制和丁酰胆碱酯酶抑制活性进行了评价,结果表明化合物1和2有微弱的乙酰胆碱酯酶抑制活性。A novel pair of Z/E isomeric compounds with unprecedented carbon skeleton were isolated from an aqueous extract of Aspongopus chinensis Dallas by macroporous resin,silica gel,and semi-preparative high performance liquid chromatography(HPLC).Their structures were identified by nuclear magnetic resonance(NMR),Infrared spectroscopy(IR),Mass spectroscopy(MS)and other spectroscopic methods as(Z)-3-(but-1″-en-1″-yl)-1-(2ʹ-hydroxyethyl)-4-propylpyridin-1-ium,namely aspongopyridine A,and(E)-3-(but-1″-en-1″-yl)-1-(2ʹ-hydroxyethyl)-4-propylpyridin-1-ium,namely aspongopyridine B,respectively.Besides,the anti-inflammatory,anti-tumor,acetylcholinesterase inhibition and butyrylcholinesterase inhibition activities of the compounds 1 and 2 were evaluated.The results showed that compounds 1 and 2 have no anti-inflammatory,anti-tumor,and butyrylcholinesterase inhibition activities instead of weak acetylcholinesterase inhibition activity.

关 键 词：九香虫 水提取物 吡啶季胺盐 新颖碳骨架 乙酰胆碱酯酶抑制活性 

分 类 号：R284[医药卫生—中药学]