ceRNA在动物低氧适应性中的研究进展  

Research progress of ceRNA in animal hypoxic adaptation

作　　者：李金铭 吴华[1] 沈童 王硕 武小庆 LI Jin-ming;WU Hua;SHEN Tong;WANG Shuo;WU Xiao-qing

机构地区：[1]青海大学农牧学院,青海西宁810016

出　　处：《饲料研究》2024年第1期153-157,共5页Feed Research

基　　金：青海省科学技术厅自然科学基金面上项目(项目编号:2022-ZJ-927)。

摘　　要：氧气是机体进行新陈代谢和维持生存的必要因素。低氧适应是机体为了适应缺氧这一生理或病理现象,降低缺氧带来的影响而发生的一系列局部性和系统性的改变。竞争性内源RNA(ceRNA)是指具有同种miRNA反应元件(MREs)的RNA分子,竞争性结合miRNA在转录后水平调控基因的表达,进而影响细胞的生物学功能。ceRNA是一种复杂的网络调节机制,在细胞增殖与凋亡、炎症反应、能量代谢、肌肉发育、脂肪沉积、脂质代谢等方面发挥作用。文章总结了长链非编码RNA(lncRNA)、环状RNA(circRNA)和假基因的生物学功能和特点,阐述经过验证的ceRNA参与动物低氧适应的生物学功能,为哺乳动物低氧适应性研究提供参考。Oxygen is an essential factor for the body's metabolism and survival.Hypoxic adaptation refers to a series of local and systemic changes that occur in the body to adapt to the physiological or pathological phenomenon of hypoxia,reducing the impact of hypoxia.Competing endogenous RNA(ceRNA)refers to RNA molecules that share the same microRNA response elements(MREs)and competitively bind to microRNAs to regulate gene expression at the posttranscriptional level,thereby influencing the biological functions of cells.ceRNA is a complex network regulation mechanism that plays a role in cell proliferation and apoptosis,inflammatory responses,energy metabolism,muscle development,fat deposition,lipid metabolism,and other aspects.The article summarizes the biological functions and characteristics of long noncoding RNA(lncRNA),circular RNA(circRNA),and pseudogenes.It elucidates the validated roles of ceRNA in the biological functions associated with animal hypoxic adaptation,providing reference for the study of mammalian hypoxia adaptability.

关 键 词：长链非编码RNA 环状RNA 假基因 竞争性内源RNA 低氧适应 

分 类 号：S813[农业科学—畜牧学]