Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms  

作　　者：Hong Yao Liping Cui Hang Liu Xueyu Li Lin Shen Ruige Yang Shangshang Qin Yong Guo 

机构地区：[1]College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China [2]School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China [3]Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,School of Pharmaceutical Science,Hengyang Medical School,University of South China,Hengyang 421001,China

出　　处：《Chinese Chemical Letters》2024年第1期52-63,共12页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.32272575);National College Student Innovation and Entrepreneurship Training Program(No.202210459164)for financial support.

摘　　要：Methicillin-resistant Staphylococcus aureus (MRSA), the most common pathogen in hospital and community environments, can cause serious and even fatal infections. The antibiotics currently used for clinical treatment of MRSA have developed resistance, and there is an urgent need to develop new antimicrobials to treat infections caused by MRSA strains. Quinoline analogues play an important role in the development of antimicrobials. Herein, we discussed the current development of antibacterial activities of quinoline analogues, mainly for anti-MRSA activity, and their structure-activity relationships (SARs) from the perspective of using the quinoline nucleus to search for novel potential anti-MRSA candidates. Additionally, the mechanisms of some representative quinoline analogues against MRSA were clarified. Altogether, this review could provide further insights for the rational development of quinoline-based antibacterial drugs, especially against MRSA.

关 键 词：Quinoline analogue Methicillin-resistant Staphylococcus aureus Antibacterial activity Structure–activity relationship Antibacterial mechanism 

分 类 号：R91[医药卫生—药学]