A H_(4)SiW_(12)O_(40)-catalyzed three-component tandem reaction for the synthesis of 3,3-disubstituted isoindolinones  

作　　者：Yufeng Liu Guodong Zeng Yutao Cheng Lei Chen Yunhai Liu Yongge Wei Guoping Yang 

机构地区：[1]School of Chemistry,Biology and Material Science,Jiangxi Province Key Laboratory of Synthetic Chemistry,Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,East China University of Technology,Nanchang 330013,China [2]Key Lab of Organic Optoelectronics&Molecular Engineering of Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China

出　　处：《Chinese Chemical Letters》2024年第1期233-236,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.22001034);Jiangxi Provincial Natural Science Foundation(No.20212BAB213001).

摘　　要：A H_(4)SiW_(12)O_(40)-catalyzed three-component tandem reaction of 2-acylbenzoic acids,primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed.By employing A H_(4)SiW_(12)O_(40)as the catalyst and dimethyl carbonate(DMC)as the solvent,a diverse range of 2-acylbenzoic acid derivatives and primary amines worked well to give the C3-phosphinoyl-functionalized 3,3-disubstituted isoindolinones with the yield range of 61%-87%.Advantages of this transformation include green catalyst and solvent,available starting materials,broad substrate scope,high efficiency and operational simplicity with water as the sole by-product.The strategy achieved an efficient and green molecular fragment assembly to access isoindolinones,which would provide opportunities for the synthesis of potential biologically active molecules in a green manner.

关 键 词：POLYOXOMETALATES Dehydrative coupling Three-component tandem reaction 3 3-Disubstituted isoindolinones Organic carbonate 

分 类 号：O62[理学—有机化学]