Eco-friendly iron-catalyzed oxidation of unstrained tertiary aromatic alcohols to ketones  

作　　者：Shanmei Zhu Penghui Hu Mengying Guo Linlin Zhao Linlin Yang Wei-Jin Gu Wei Han 

机构地区：[1]Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China

出　　处：《Chinese Chemical Letters》2024年第1期250-253,共4页中国化学快报（英文版）

基　　金：the Natural Science Foundation of China(No.21776139);the“Qing Lan Project”Young and Middle-aged Academic Leaders of Jiangsu Provincial Colleges and Universities,and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

摘　　要：A general,facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through C-C bond cleavage even with H_(2)O_(2) as the oxidant.Notably,this transformation can tolerate oxidation-labile functional groups.The robustness of this method is further demonstrated on the late-stage oxidation of complex bioactive molecules.

关 键 词：Iron catalysis C-C bond cleavage Oxidation H_(2)O_(2) Late-stage functionalization 

分 类 号：O621.251[理学—有机化学] O625.42[理学—化学]