Recognition and chirality sensing of guanosine-containing nucleotides by an achiral tetraphenylethene-based octacationic cage in water  

作　　者：Honghong Duan Ting Yang Qingfang Li Fan Cao Pingxia Wang Liping Cao 

机构地区：[1]College of Chemistry and Materials Science,Northwest University,Xi'an 710069,China

出　　处：《Chinese Chemical Letters》2024年第1期267-270,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22122108 and 21971208);the Natural Science Basic Research Plan for Distinguished Young Scholars in Shaanxi Province of China(No.2021JC-37);the Fok Ying Tong Education Foundation(No.171010).

摘　　要：The development of molecular probes or systems with the ability of multiple orthogonal responses is an effective approach to precisely detect biomolecules with similar chemical structures.Herein,we report the synthesis of a water-soluble TPE-based octacationic cage(1)with the compressed TPE-containing bilayer,which endows it with good fluorescence properties and potential conformation chirality.As a result,1 exhibits molecular recognition for anionic nucleotides within its two“claw”-like cavities to form 1:2 host-guest complexes in water,companying with selective turn-off fluorescence and turn-on CD responses to G/GTP over other nucleotides.

关 键 词：Host-guest recognition Chirality sensing Tetraphenylethene Achiral cage Nucleotide 

分 类 号：O657[理学—分析化学]