Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor  

作　　者：Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng Jinxing Ye 

机构地区：[1]School of Biomedical and Pharmaceutical Sciences,Guangdong University of Technology,Guangzhou 510006,China [2]School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China [3]School of Chemical Engineering,East China University of Science and Technology,Shanghai 200237,China [4]Shanghai No.1 Biochemical&Pharmaceutical Co.,Ltd.,Shanghai 200080,China

出　　处：《Chinese Chemical Letters》2024年第1期290-294,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.22278087)。

摘　　要：A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS production.We constructed a telescoped two-step continuous flow platform.This involved a continuous tanshinone IIA sulfonation and in-line salt formation.For the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser micromachining.Compared to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal conditions.The proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production.

关 键 词：Continuous flow Sodium tanshinone IIA sulfonate Cardiovascular MICROREACTOR Green chemistry 

分 类 号：TQ460.6[化学工程—制药化工]