H_(2)S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection  

作　　者：Peng Shan Jing Liao Jiayi Li Chengyan Wang Jie Zhou Linqiang Mei Yunlu Dai Qiang Wang Wenyan Yin 

机构地区：[1]Laboratory for Micro-sized Functional Materials,Department of Chemistry and College of Elementary Education,Capital Normal University,Beijing 100048,China [2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China [3]Department of Pharmacy,Southwest Hospital,The Third Military Medical University,Chongqing 400038,China [4]Cancer Centre and Institute of Translational Medicine,Faculty of Health Sciences,University of Macao,Macao SAR 999078,China

出　　处：《Chinese Chemical Letters》2024年第1期392-400,共9页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22175182,21471103);Sheng Yuan Cooperation(No.2021SYHZ0048);Beijing Natural Science Foundation(No.2202064);the directional institutionalized scientific research platform relies on Beijing Synchrotron Radiation Facility of Chinese Academy of Sciences.

摘　　要：Radiation damage can cause a series of gastrointestinal(GI)tract diseases.The development of safe and effective GI tract radioprotectants still remains a great challenge clinically.Here,we firstly report an oral radioprotectant Gel@GYY that integrates a porous gelatin-based(Gel)hydrogel and a pH-responsive hydrogen sulfide(H2S)donor GYY4137(morpholin-4-ium 4 methoxyphenyl(morpholino)phosphinodithioate).Gel@GYY has a remarkable adhesion ability and long retention time,which not only enables responsive release of low-dose H2S in stomach and subsequently sustained release of H2S in the whole intestinal tract especially in the colon,but also ensures a close contact between H2S and GI tract.The released H2S can effectively scavenge free radicals induced by X-ray radiation,reduce lipid peroxidation level,repair DNA damage and recover vital superoxide dismutase and glutathione peroxidase activities.Meanwhile,the released H2S inhibits radiation-induced activation of nuclear factorκB(NF-κB),thus reducing inflammatory cytokines levels in GI tract.After treatment,Gel@GYY displays efficient excretion from mice body due to its biodegradability.This work provides a new insight for therapeutic application of intelligent H2S-releasing oral delivery system and potential alternative to clinical GI physical damage protectant.

关 键 词：Radiation Gastrointestinal tract radioprotection Hydrogen sulfide gas therapy Gelatin-based hydrogel Free radicals scavenging 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]