补体在增生性瘢痕形成中的作用研究进展  

Research progress on the complement in hypertrophic scar formation

作　　者：刘嘉萍 袁观斗 韩志强[1,2,3] 何松青 Liu Jiaping;Yuan Guandou;Han Zhiqiang;He Songqing(Division of Hepatobiliary Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,Nanning 530021,China;Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院肝胆外科,南宁530021 [2]区域性高发肿瘤早期防治研究教育部重点实验室(广西医科大学),南宁530021 [3]广西肝脏疾病免疫与代谢研究重点实验室,南宁530021

出　　处：《中华实验外科杂志》2023年第12期2659-2662,共4页Chinese Journal of Experimental Surgery

基　　金：高等学校学科创新引智计划(D17011);广西医科大学高水平创新团队及杏湖学者计划;广西壮族自治区卫生健康委西医类自筹经费科研课题(Z-A20220428);广西医科大学2022年大学生创新创业训练计划项目(02616222301X);广西医科大学2022年"未来学术之星"课外创新课题项目(02612222095X)。

摘　　要：增生性瘢痕是胶原纤维过度沉积的病理性愈合结果。创面修复过程中异常的胶原调节是增生性瘢痕形成的关键步骤。补体系统作为免疫系统的重要组成部分,通过多个途径影响瘢痕组织的胶原合成、降解和重塑,与增生性瘢痕的发生发展密切相关。本文就补体及其信号通路在增生性瘢痕形成中的作用进行综述。Hypertrophic scar is a pathological healing outcome characterized by excessive deposition of collagen fibers.Aberrant collagen regulation during the wound repair process is a crucial step in the development of hypertrophic scars.As an integral part of the immune system,the complement system exerts significant influence on collagen synthesis,degradation,and remodeling in scar tissue,closely contributing to the occurrence and progression of hypertrophic scars.This article provides an overview of the role of the complement system and its signaling pathways in the formation of hypertrophic scars.

关 键 词：补体 增生性瘢痕 胶原 纤维化 

分 类 号：R622[医药卫生—整形外科]