常间回文重复序列丛集/关联蛋白系统技术在肥胖及相关疾病研究进展  

Dynamic analysis of clustered regularly interspaced short palindromic repeats/CRISPR-associated protein system in obesity and related disorders research:a review

作　　者：张艺超[1] 胡钰 董志勇[1] 黄波 王存川[1] Zhang Yichao;Hu Yu;Dong Zhiyong;Huang Bo;Wang Cunchuan(Department of General Surgery,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China;Department of Radiology,the Second Affiliated Hospital of Shenzhen University,Shenzhen 518101,China;Department of General Surgery,the Second Affiliated Hospital of Shenzhen University,Shenzhen 518101,China)

机构地区：[1]暨南大学附属第一医院胃肠外科,广州510630 [2]深圳大学附属第二医院放射科,深圳518101 [3]深圳大学附属第二医院普通外科二区,深圳518101

出　　处：《中华实验外科杂志》2023年第12期2682-2690,共9页Chinese Journal of Experimental Surgery

摘　　要：肥胖及相关疾病已成为全球公共卫生问题。在精准医疗时代的背景下,基因编辑技术为肥胖及相关疾病的治疗和基因组学研究提供了更加精确和个性化的方案。常间回文重复序列丛集/关联蛋白系统(CRISPR/Cas)基因编辑比其他技术的效率更高,可以通过对特定基因进行敲除、插入等操作实现基因组的定点修饰。其中CRISPR/Cas9作为目前最高效便捷的基因编辑技术之一,其应用将有可能引领肥胖相关疾病诊断与治疗进入一个崭新发展阶段。本文基于Pub Med数据库通过对CRISPR/Cas技术在肥胖及相关疾病研究进行文献动态态势分析,对相关热点文献进行综述,并提供部分相关基因调控图录作研究参考。Obesity and its associated diseases have emerged as a significant global public health challenge.In the era of precision medicine,gene editing technology offers more precise and personalized approaches for treating obesity and related conditions.clustered regularly interspaced short palindromic repeats/CRISPR-associated protein(CRISPR/Cas)gene editing is particularly efficient compared to other techniques,enabling precise modifications in the genome through gene knockout,insertion,and other manipulations.Among these techniques,CRISPR/Cas9 stands out as one of the most effective and convenient methods currently available,with the potential to revolutionize genomic research.In this study,we conducted a dynamic analysis of the literature on CRISPR/Cas in obesity and related disorders research using the PubMed database.We reviewed relevant high-impact articles and provided a collection of gene regulation figures that serve as valuable references for future studies.

关 键 词：常间回文重复序列丛集/其关联蛋白系统 基因编辑技术 肥胖 代谢性疾病 文献动态分析 综述 

分 类 号：R589.2[医药卫生—内分泌]