PM_(2.5)影响2型糖尿病分子机制的研究进展  

Research progress on molecular mechanism of PM_(2.5) affecting type 2 diabetes

作　　者：张钰棋 张瑛 曹运长 王五香[3] 封少龙 ZHANG Yuqi;ZHANG Ying;CAO Yunchang;WANG Wuxiang;FENG Shaolong(The Institute of Preventive Medicine/Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health,School of Public Health,Guilin Medical University,Guilin 541199,China;The School of Intelligent Medicine and Biotechnology,Guilin Medical University,Guilin 541199,China;The Library of University of South China,Hengyang 421001,China;The State Key Laboratory of Organic Geochemistry,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,China)

机构地区：[1]桂林医学院公共卫生学院,广西环境暴露组学与全生命周期健康重点实验室/预防医学研究所,桂林541199 [2]桂林医学院智能医学与生物技术学院,桂林541199 [3]南华大学图书馆,衡阳421001 [4]中国科学院广州地球化学研究所有机地球化学国家重点实验室,广州510640

出　　处：《生命的化学》2023年第12期1847-1853,共7页Chemistry of Life

基　　金：国家自然科学基金项目(41877390);有机地球化学国家重点实验室开放基金项目(SKLOG-202213)。

摘　　要：大气PM_(2.5)污染暴露可对人体健康产生多种不良影响,其中,促进糖尿病发生发展是其影响健康的重要途径。本文继细述了PM_(2.5)主要通过氧化应激、炎症反应、线粒体功能障碍、内质网应激等分子机制影响2型糖尿病发生发展之后,探讨了铁死亡可能参与PM_(2.5)致2型糖尿病发生发展的进程,并指出了深入研究PM_(2.5)致2型糖尿病发生发展机制的紧迫性,以期为相关部门的科学决策和为新学者提供基础科学资料。Exposure of atmospheric PM_(2.5) pollution has a variety of adverse effects on human health,among which promoting the occurrence and development of diabetes is an important way to affect health.In this review,after elaborating that PM_(2.5) affects the occurrence and development of type 2 diabetes mainly through molecular mechanisms,such as oxidative stress,inflammatory reaction,mitochondrial dysfunction and endoplasmic reticulum stress,we have also discussed that ferroptosis might participate in the process of the occurrence and development of type 2 diabetes caused by PM_(2.5) exposure,and pointed out that it was urgent to further study the underlying molecular mechanisms of the occurrence and development of type 2 diabetes caused by PM_(2.5).The aim is to provide basic scientific information for both scientific decision-making of the relevant departments and newcomers in this researching field.

关 键 词：PM_(2.5) 2型糖尿病 氧化应激 炎症反应 铁死亡 

分 类 号：R587.1[医药卫生—内分泌]