羟基磷灰石/氧化石墨烯复合支架在骨缺损修复治疗中的研究进展  

Research progress on hydroxyapatite/graphene oxide composite scaffolds in the treatment of bone defect repair

作　　者：杨宁文 何星[1] YANG Ningwen;HE Xing(Department of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学材料与化学学院,上海200093

出　　处：《复合材料学报》2024年第1期38-49,共12页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金资助项目(51202147)。

摘　　要：骨缺损引起的骨疾病是现代医学非常棘手的一种疾病,正常的骨组织发生病变或外部因素的物理损伤都会形成难愈合的骨缺损;骨缺损部位复杂的微环境决定其治疗条件也更苛刻。构建可以用于骨缺损的支架是骨组织工程技术的一个重要方向,也是解决骨缺损疾病难题的重要手段。本文简单介绍了羟基磷灰石/氧化石墨烯(HA/GO)复合材料的制备原理和方法,细胞实验表明HA/GO对骨细胞没有明显的毒性,粗糙的表面结构更有利于骨细胞的增殖分化,在此基础上详细介绍了用于治疗骨缺损疾病HA/GO复合支架的构建方式及其性能。最后讨论了HA/GO复合支架在骨疾病治疗中的发展前景和面临的挑战。Bone defects caused by bone diseases are a very challenging issue in modern medicine.Both pathological changes in normal bone tissue and physical damage caused by external factors can lead to difficult-to-heal bone defects.The complex microenvironment of the bone defect site makes treatment conditions more demanding.Constructing scaffolds for bone defects is an important direction in bone tissue engineering technology and a crucial means to solve the problem of bone defect diseases.This article briefly introduces the preparation principles and methods of hydroxyapatite/graphene oxide(HA/GO)composite materials.HA/GO has no apparent toxicity to bone cells,and its rough surface structure is more conducive to the proliferation and differentiation of bone cells.Based on this,the construction methods and performance of HA/GO composite scaffolds for treating bone defect diseases are described in detail.Finally,the development prospects and challenges of HA/GO composite scaffolds in the treatment of bone diseases are discussed.

关 键 词：氧化石墨烯 羟基磷灰石 骨疾病 复合支架 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]