大孔径有机/无机复合功能Janus笼的制备及其对油相的pH响应性吸释  

Preparation of organic/inorganic composite functional Janus cages with large aperture and their pH-responsive absorption and release of the oil

作　　者：斯炎 石思宇 井静云 SI Yan;SHI Siyu;JING Jingyun(Postdoctoral Research Station of Zhongguancun Smart City CO.,LTD.,Substation of Zhongguancun Haidian Yuan Postdoctoral Centre,Beijing 100081,China;Aerospace Science&Industry Defense Technology Research and Test Center,Beijing 100854,China;Beijing Key Laboratory of Metro Fire and Passenger Transportation Safety,China Academy of Safety Science and Technology,Beijing 100012,China)

机构地区：[1]中关村海淀园博士后科研工作站中关村科学城城市大脑股份有限公司分站,北京100081 [2]航天科工防御技术研究试验中心,北京100854 [3]中国安全生产科学研究院地铁火灾与客流疏运安全北京市重点实验室,北京100012

出　　处：《复合材料学报》2024年第1期307-314,共8页Acta Materiae Compositae Sinica

摘　　要：Janus笼独特的内外表面化学性质或组成的非对称性使其可以用作特殊微容器,用于分离富集、传输和受限反应等。在一定程度上,更大的孔径能够加强Janus笼和环境之间的物质传输效率。本文介绍了一种两步制备具有pH响应性的大孔径磁性有机/无机复合Janus笼的方法。首先是通过乳液界面硅烷偶联剂的溶胶凝胶和两种表面活性剂在界面微相分离制备支撑性良好、表面孔径可调的磁性无机Janus笼。其内表面修饰上的卤素基团可通过可控自由基聚合接枝上pH响应性聚合物得到聚合物/无机复合功能Janus笼。通过SEM、TEM、FTIR及TGA对复合Janus笼进行表征,其粒径在1~3μm,孔径在40 nm~1μm可调,聚合物的质量占复合笼的41.7wt%。制备的复合Janus笼可以通过改变环境pH值控制其对油相的富集和释放,并可同时通过磁操控实现定向传输,有望用于药物装载和体内靶向释放等领域。The unique asymmetry of chemistry or composition of external and internal surface for Janus cage allows it to be used as a special microcontainer for separation,enrichment,transport and restricted reactions.To some extent,large aperture of cage can enhance the material transport efficiency between microcontainer and the environment.A two-step method to prepare magnetic organic/inorganic composite Janus cages with large aperture and pH responsiveness was introduced in this paper.Firstly,a magnetic inorganic Janus cage with a well-supported shell and adjustable aperture was prepared by the sol-gel of silane coupling agents and microphase separation of two surfactants at the interface.Then pH-responsive polymer poly diethylaminoethyl methacrylate(PDEAEMA)was grafted on the interior surface of inorganic Janus cage by Cu-mediated controlled radical polymerization to obtain functional Janus composite cages.SEM,TEM,FTIR and TGA were performed on composite cages.The size of cages is about 1-3μm,with tunable pore size from 40 nm to 1μm.The proportion of polymer in the composite cages is 41.7wt%.Controlled absorption and release of oil and oriented transport of substance can be achieved by changing pH and magnetic manipulation respectively with these composite Janus cages,which means it is promising for drug loading and targeted release in vivo.

关 键 词：大孔径 复合Janus笼 PH响应性 磁操控 可控吸释 

分 类 号：TB332[一般工业技术—材料科学与工程]