Rab蛋白在自噬中的作用  

Role of rab protein in autophagy

作　　者：梁凯 刘媛[1,2,3,4] 周策凡 唐景峰 LIANG Kai;LIU Yuan;ZHOU Cefan;TANG Jingfeng(National“111”Center for Cellular Regulation and Molecular Pharmaceutics,Hubei University of Technology,Wuhan 430068,China;Key Laboratory of Fermentation Engineering(Ministry of Education),Hubei University of Technology,Wuhan 430068,China;Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province),Hubei University of Technology,Wuhan 430068,China;Hubei Key Laboratory of Industrial Microbiology,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学科技部/教育部细胞调控与分子药物学科“111”引智基地,湖北武汉430068 [2]湖北工业大学发酵工程教育部重点实验室,湖北武汉430068 [3]湖北工业大学工业发酵省部共建协同创新中心,湖北武汉430068 [4]湖北工业大学工业微生物湖北省重点实验室,湖北武汉430068

出　　处：《生物技术》2023年第6期785-790,797,共7页Biotechnology

基　　金：国家自然基金面上项目(31871176,32070726)。

摘　　要：Rab蛋白存在于所有的真核细胞中,是囊泡运输和融合过程的关键调节因子,对细胞内囊泡的出芽、脱壳、运动和融合起重要作用。自噬是维持细胞稳态及正常生理活动的重要过程。许多Rab蛋白已被证明参与自噬的各个阶段。该文重点对不同的Rab蛋白在Rab蛋白的结构和功能以及自噬过程中的调节作用机制和研究进展进行综述,为基于自噬相关疾病的防治提供新的治疗靶点。The Rab protein is present in all eukaryotic cells and is a key regulator of vesicle transport and fusion processes,playing an important role in the budding,decoating,motility,and fusion of intracellular vesicles.Autophagy is an important process for maintaining cell homeostasis and normal physiological activities.Many Rab proteins have been shown to be involved in various stages of autophagy.This article focuses on the structure and function of different Rab proteins in the structure and function of Rab proteins,as well as the regulatory mechanism and research progress of autophagy,so as to provide new therapeutic targets for the prevention and treatment of autophagy-related diseases.

关 键 词：RAB蛋白 囊泡运输 自噬 机制 疾病 

分 类 号：Q291[生物学—细胞生物学]