孤独症谱系障碍中硫醇-二硫化物稳态的研究进展  

Advances of thiol-disulfide homeostasis in autism spectrum disorders

作　　者：石嫒 张新明 李颖[4] 谢芳[4] 吴辉文[5] 王军[1,2,3] SHI Ai;ZHANG Xinming;LI Ying;XIE Fang;WU Huiwen;WANG Jun(Provincial Ministry of Industrial Fermentation Co-operative Innovation Centre,Hubei University of Technology,Wuhan 430068,China;Institue of Autism Depression and Intervention,Hubei University of Technology,Wuhan 430068,China;Cellular Regulation and Molecular Pharmaceutics Introduction Center for Discipline Innovation(“111”Center),Hubei University of Technology,Wuhan 430068,China;Huangshi Maternal and Child Health Hospital,Huangshi 435002,China;Hubei Maternal and Child Health Hospital for Children,Wuhan 430075,China)

机构地区：[1]湖北工业大学工业发酵省部共建协同创新中心,湖北武汉430068 [2]湖北工业大学孤独症抑郁症与干预研究所,湖北武汉430068 [3]湖北工业大学,国家外专局/教育部“细胞调控与分子药物”学科创新111引智基地,湖北武汉430068 [4]黄石市妇幼保健院,湖北黄石435002 [5]湖北省妇幼保健院儿童保健科,湖北武汉430075

出　　处：《生物技术》2023年第6期791-797,共7页Biotechnology

基　　金：国家自然科学基金项目(82061138005);湖北省教育厅创新团队项目(T2020009)。

摘　　要：硫醇-二硫化物具有调节细胞内氧化还原平衡的作用,其稳态的损伤不仅会加剧氧化应激的发展,还与多种疾病的致病机制相关。近年来,孤独症谱系障碍(autism spectrum disorders,ASD)中的硫醇-二硫化物也引起了越来越多的关注。该文首先对硫醇-二硫化物的分类和生物学功能进行阐述,以及ASD体内硫醇-二硫化物稳态的变化,分析了硫醇-二硫化物对ASD可能的作用机制,总结了硫醇-二硫化物在ASD致病机制中通过抗氧化防御、抗炎性反应和调节神经发育而发挥作用。Thiol-disulfides have a role in regulating intracellular redox homeostasis,and impairment of their homeostasis not only exacerbates the development of oxidative stress,but is also implicated in the pathogenesis of a number of diseases.In recent years,thiol-disulfides in autism spectrum disorders(ASD)have also attracted increasing attention.This paper firstly describes the classification and biological functions of thiol-disulfides and the changes in thiol-disulfide homeostasis in ASD,analyses the possible mechanisms of thiol-disulfide action in ASD,and concludes that thiol-disulfides play a role in the pathogenesis of ASD through antioxidant defense,anti-inflammatory responses and regulation of neurodevelopment.

关 键 词：硫醇-二硫化物 孤独症谱系障碍 稳态 氧化应激 谷胱甘肽 神经发育 半胱氨酸 炎症 

分 类 号：Q189[生物学—神经生物学]