Bioengineered materials with selective antimicrobial toxicity in biomedicine  

作　　者：Pooyan Makvandi Hao Song Cynthia K.Y.Yiu Rossella Sartorius Ehsan Nazarzadeh Zare Navid Rabiee Wei-Xi Wu Ana Cláudia Paiva-Santos Xiang-Dong Wang Cheng-Zhong Yu Franklin R.Tay 

机构地区：[1]The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Quzhou 324000,Zhejiang,China [2]Istituto Italiano di Tecnologia,Centre for Materials Interfaces,Pontedera 56025,Italy [3]Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,Brisbane,QLD 4072,Australia [4]Paediatric Dentistry and Orthodontics,Faculty of Dentistry,The University of Hong Kong,Prince Philip Dental Hospital,Hong Kong SAR,China [5]Institute of Biochemistry and Cell Biology(IBBC),National Research Council(CNR),80131 Naples,Italy [6]School of Chemistry,Damghan University,Damghan 36716‑45667,Iran [7]School of Engineering,Macquarie University,Sydney,NSW 2109,Australia [8]Centre for Molecular Medicine and Innovative Therapeutics,Murdoch University,Perth,WA 6150,Australia [9]Department of Pharmaceutical Technology,Faculty of Pharmacy of the University of Coimbra,University of Coimbra,3000‑548 Coimbra,Portugal [10]REQUIMTE/LAQV,Group of Pharmaceutical Technology,Faculty of Pharmacy of the University of Coimbra,University of Coimbra,3000‑548 Coimbra,Portugal [11]Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital,Fudan University Shanghai Medical College,Shanghai 200032,China [12]School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200241,China [13]The Graduate School,Augusta University,Augusta,GA 30912,USA

出　　处：《Military Medical Research》2023年第6期798-817,共20页军事医学研究（英文版）

摘　　要：Fungi and bacteria afflict humans with innumerous pathogen-related infections and ailments.Most of the commonly employed microbicidal agents target commensal and pathogenic microorganisms without discrimination.To distinguish and fight the pathogenic species out of the microflora,novel antimicrobials have been developed that selectively target specific bacteria and fungi.The cell wall features and antimicrobial mechanisms that these microorganisms involved in are highlighted in the present review.This is followed by reviewing the design of antimicrobials that selectively combat a specific community of microbes including Gram-positive and Gram-negative bacterial strains as well as fungi.Finally,recent advances in the antimicrobial immunomodulation strategy that enables treating microorganism infections with high specificity are reviewed.These basic tenets will enable the avid reader to design novel approaches and compounds for antibacterial and antifungal applications.

关 键 词：Antimicrobial nanotechnology Immumodualtion Selective toxicity Smart nanomaterials Targeting microorganism 

分 类 号：R318[医药卫生—生物医学工程]