PI4P STimulatING innate immune activation:beyond the Golgi  

作　　者：Yi Zheng Xuejing Zhang Chengjiang Gao 

机构地区：[1]Key Laboratory of Infection and Immunity of Shandong Province,Department of Immunology,School of Basic Medical Sciences,Shandong University,Jinan,250012,Shandong,China

出　　处：《Cellular & Molecular Immunology》2023年第12期1399-1400,共2页中国免疫学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82271788,81930039,and 32230033);the Future Scholar Program of Shandong University,and the Natural Science Foundation of Shandong Province(ZR2022YQ70).

摘　　要：The cGAS–STING pathway is pivotal for sensing cytosolic DNA[2].cGAS,a cytoplasmic DNA sensor,can be stimulated by DNA,and it consumes ATP and GTP to synthesize a second messenger,2'3'-cGAMP,which binds to STING,resulting in STING conformational change,oligomerization,and activation;ultimately,this process leads to the production of cytokines such as type I interferon to mediate antiviral and antitumor immune responses(Fig.1).Phosphoinositides,derived from phosphatidylinositol(PI),are phospholipids in membranes and are also crucial signaling molecules[3].The D-3,D-4,or D-5 positions in the inositol head group can be phosphorylated;therefore,a total of seven different PIP molecules exist in eukaryotes.Phosphatidylinositol 4-phosphate(PI4P)is distributed in various membrane components,with the highest amount in the trans-Golgi network(TGN)[4].The PI4P level in cells is regulated by its PI4K synthetases(PI4KA,PI4KB,PI4K2A,and PI4K2B)and the lipid phosphatase SAC1.In addition to being a precursor for PIP2 and PIP3,PI4P is a crucial signaling molecule involved in vesicular transport,lipid transport,and organelle morphology maintenance.

关 键 词：ACTIVATION POSITIONS SYNTHESIZE 

分 类 号：R392[医药卫生—免疫学]