Emerging drug design strategies in anti-influenza drug discovery  

作　　者：Chuanfeng Liu Lide Hu Guanyu Dong Ying Zhang Edeildo Ferreira da Silva-Jinior Xinyong Liu Luis Menendez-Arias Peng Zhan 

机构地区：[1]Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China [2]Laboratory of Medicinal Chemistry,Institute of Pharmaceutical Sciences,Federal University of Alagoas,Maceio 57072-970,Alagoas,Brazil [3]Centro de Biologia Molecular“Severo Ochoa”(Consejo Superior de Investigaciones Cientificas&Universidad Autonoma de Madrid),Madrid 28049,Spain

出　　处：《Acta Pharmaceutica Sinica B》2023年第12期4715-4732,共18页药学学报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(NSFC No.82173677);the Science Foundation for Outstanding Young Scholars of Shandong Province(ZR2020JQ31,China);the China Postdoctoral Science Foundation(2022M711938);supported in part by the Ministry of Science and Innovation of Spain through grant PID2019-104176RB-I00/AEI/10.13039/501100011033 awarded to Luis Menendez-Arias-A.

摘　　要：Influenza is an acute respiratory infection caused by influenza viruses(IFV),According to the World Health Organization(WHO),seasonal IFV epidemics result in approximately 3-5 million cases of severe illness,leading to about half a million deaths worldwide,along with severe economic losses and social burdens.Unfortunately,frequent mutations in IFV lead to a certain lag in vaccine development as well as resistance to existing antiviral drugs.Therefore,it is of great importance to develop anti-IFV drugs with high efficiency against wild-type and resistant strains,needed in the fight against current and future outbreaks caused by different IFV strains.In this review,we summarize general strategies used for the discovery and development of antiviral agents targeting multiple IFV strains(including those resistant to available drugs).Structure-based drug design,mechanism-based drug design,multivalent interaction-based drug design and drug repurposing are amongst the most relevant strategies that provide a framework for the development of antiviral drugs targeting IFV.

关 键 词：Influenza virus Drug design strategies Anti-drugresistance High efficiency Broad spectrum 

分 类 号：R51[医药卫生—内科学]