分析血清CHE联合CHOL、ALB检测对肝硬化伴睡眠障碍患者睡眠状态、检测率的影响  

Analysis of the Effects of Serum CHE Combined with CHOL and ALB Detection on Sleep Status and Detection Rate in Patients with Liver Cirrhosis and Sleep Disorders

作　　者：张巧梅 ZHANG Qiaomei(Third People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China)

机构地区：[1]福建中医药大学附属第三人民医院,福州350108

出　　处：《世界睡眠医学杂志》2023年第10期2267-2269,共3页World Journal of Sleep Medicine

摘　　要：目的:分析血清CHE联合CHOL、ALB检测对肝硬化伴睡眠障碍患者睡眠状态、检测率的影响。方法:选取2020年4月至2023年4月福建中医药大学附属第三人民医院医学检验科收治的肝硬化伴睡眠障碍患者70例作为观察组,另选取同时期70例患病但不伴有睡眠障碍的患者作为对照组。2组均接受血清胆碱酯酶(CHE)、胆固醇(CHOL)、清蛋白(ALB)水平检测,以实际情况作为金标准,比较2组血清CHE、CHOL、ALB水平,不同肝功能分级患者的血清CHE、CHOL、ALB水平以及睡眠状态,分析血清CHE、CHOL、ALB单项检查以及联合检验的检出率、不同肝硬化程度的睡眠障碍严重程度。结果:观察组血清CHE、CHOL、ALB水平均显著低于对照组;观察组A级、B级、C级之间的血清CHE、CHOL、ALB水平均存在显著差异,A级肝硬化患者的血清CHE、CHOL、ALB水平均较高于B级、C级;以肝硬化伴睡眠障碍为自变量(非肝硬化伴睡眠障碍=0,肝硬化伴睡眠障碍=1),以血清CHE、CHOL、ALB表达水平为因变量,绘制ROC曲线,结果显示,CHE、CHOL、ALB联合诊断肝硬化伴睡眠障碍的曲线下面积(0.926,95%Cl为0.754~0.943)高于单一指标,灵敏度、特异度分别为98.57%、97.14%(均P<0.05)。结论:肝硬化伴睡眠障碍患者的血清CHE、CHOL、ALB水平较低,肝硬化程度高的患者血清CHE、CHOL、ALB水平下降,血清CHE、CHOL、ALB联合检验有助于肝硬化伴睡眠障碍进行诊断,有较高的敏感度、特异度。Objective:To analyze the effect of serum CHE combined with CHOL and ALB detection on the sleep status and detection rate of patients with liver cirrhosis and sleep disorders.Methods:A total of 70 patients with liver cirrhosis and sleep disorders admitted to the Medical Laboratory Department of the Third People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from April 2020 to April 2023 were selected as the observation group,and another 70 patients with disease but no sleep disorders during the same period were selected as the control group.Both groups received serum levels of cholinesterase(CHE),cholesterol(CHOL),and albumin(ALB).The actual situation was used as the gold standard to compare the serum levels of CHE,CHOL,and ALB between the two groups,as well as the serum levels of CHE,CHOL,and ALB and sleep status of patients with different liver function grades.The detection rates of serum CHE,CHOL,and ALB single and combined tests were analyzed,as well as the severity of sleep disorders in different degrees of liver cirrhosis.Results:The serum levels of CHE,CHOL,and ALB in the observation group were significantly lower than those in the control group.There were significant differences in serum CHE,CHOL,and ALB levels among grade A,B,and C in the observation group.The serum CHE,CHOL,and ALB levels in grade A cirrhosis patients were higher than those in grade B and C.Using liver cirrhosis with sleep disorders as the independent variable(non liver cirrhosis with sleep disorders=0,liver cirrhosis with sleep disorders=1)and serum CHE,CHOL,and ALB expression levels as the dependent variable,ROC curves were plotted.The results showed that the AUC(0.926,95%CI 0.754 to 0.943)under the curve for the combined diagnosis of liver cirrhosis with sleep disorders was higher than that of a single indicator,with sensitivity and specificity of 98.57%and 97.14%,respectively(P s<0.05).Conclusion:The serum levels of CHE,CHOL,and ALB are lower in patients with liver cirrhosis accompanied by sleep disorder

关 键 词：肝硬化 睡眠障碍 胆碱酯酶 胆固醇 清蛋白 

分 类 号：R657.31[医药卫生—外科学] R338.63[医药卫生—临床医学]