细菌中blaTEM耐药基因研究现状及展望  

Research status and prospect of antibiotic resistance gene blaTEM in bacteria

作　　者：肖林林 龙雨霖[2] 董庆利 Xiao Linlin;Long Yulin;Dong Qingli(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Department of Laboratory Medicine,Shanghai Sixth People′s Hospital(South Campus)Affiliated to Shanghai Jiao Tong University,Shanghai 201499,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海交通大学附属第六人民医院南院检验科,上海201499

出　　处：《中华微生物学和免疫学杂志》2023年第12期918-924,共7页Chinese Journal of Microbiology and Immunology

基　　金：上海市卫生健康委员会青年课题(20204Y0183)。

摘　　要：β-内酰胺类抗生素是临床上广泛应用的一类抗生素,其抗菌机制是通过抑制细菌的细胞壁合成来达到杀菌的效果。然而,由于β-内酰胺类耐药基因在菌株间的广泛传播,导致β-内酰胺类抗生素的使用受到了极大的挑战。其中,blaTEM耐药基因是β-内酰胺酶的主要编码基因之一,迄今已鉴定出243个blaTEM亚型,其在抗生素耐药性研究中具有极其重要的地位。本文将从blaTEM基因的发现、结构及启动子,blaTEM基因的分布和传播,blaTEM基因的耐药机制以及研究现状进行综述,旨在为细菌中β-内酰胺类耐药基因亚型的研究提供借鉴。β-lactam antibiotics are a class of antibiotics widely used in clinical treatment.The antibacterial mechanism of them is to inhibit the cell wall synthesis of bacteria.However,the widespread ofβ-lactam resistance genes among bacteria has posed a great challenge to the use ofβ-lactam antibiotics.One of the main genes encodingβ-lactamase is blaTEM,and 243 subtypes of it have been identified to date.Studying blaTEM gene is of great significance in antibiotic resistance research.This review focused on the discovery,structure,promoter,distribution,spread,antibacterial mechanism and research status of blaTEM gene,hoping to provide reference for further research on the subtypes ofβ-lactam resistance genes in bacteria.

关 键 词：blaTEM Β-内酰胺酶 耐药机制 启动子 

分 类 号：R446.5[医药卫生—诊断学]