吸烟对不育症男性精液质量的影响  

The Effect of Smoking on the Semen Quality in Male Infertile

作　　者：姚颖杰[1] 蔡金凤[1] 侯江厚 陈云雁[1] 夏明 杨海云[3] 肖彭莹[1] 王丽君 YAO Yingjie;CAI Jinfeng;HOU Jianghou;CHEN Yunyan;XIA Ming;YANG Haiyun;XIAO Pengying;WANG Lijun(Dept.of Reproductive Health and Infertility,Kunming Maternal and Child Health Hospital,Kunming Yunnan 650032,China;Clinical Translational Center,Kunming Maternal and Child Health Hospital,Kunming Yunnan 650032,China;Grassroots Guidance Section,Kunming Maternal and Child Health Hospital,Kunming Yunnan 650032,China;Dept.of Gynecology,Kunming Maternal and Child Health Hospital,Kunming Yunnan 650032,China)

机构地区：[1]昆明市妇幼保健院生殖健康与不孕不育科,云南昆明650032 [2]昆明市妇幼保健院临床转化中心,云南昆明650032 [3]昆明市妇幼保健院基层指导科,云南昆明650032 [4]昆明市妇幼保健院妇科,云南昆明650032

出　　处：《昆明医科大学学报》2024年第1期163-167,共5页Journal of Kunming Medical University

基　　金：昆明市卫生科技人才培养基金资助项目(2021-百工程-28)。

摘　　要：目的 探究吸烟对不育症男性精液质量的影响。方法 选取360例男性不育症患者,根据患者是否吸烟进行分组:吸烟组(n=190)和未吸烟组(n=170,N组),其中吸烟组按照吸烟量分为A组(≤10支/d组,n=63)、B组(11~20支/d组,n=80)、C组(>20支/d组,n=47)。观察并进行组间、组内比较各组患者精液量、液化时间、精子浓度、活动力、DNA碎片率以及正常形态率。结果 吸烟组和未吸烟组精液量、液化时间、精子活动力、正常形态率以及DNA碎片率比较差异均有统计学意义(P <0.05),吸烟组患者精液量、精子活动力以及正常形态率低于未吸烟组,DNA碎片率、精液液化时间高于未吸烟组。且随着吸烟量增加,精子活动力以及正常形态率下降,精液液化时间、DNA碎片率增加;吸烟组和未吸烟组精子浓度比较差异无统计学意义(P>0.05)。吸烟量不同的3个组精液量比较差异无统计学差异(P>0.05)。结论 吸烟对精液量、精子活性、正常形态率、精子活动力、液化时间及DNA碎片化等精子质量参数造成负面影响,大量吸烟影响尤为明显。应该加强全面健康教育、提倡健康的生活方式、减少吸烟。Objective To investigate the effect of smoking on the semen quality in infertile men.Methods n A total of 360 male infertility patients were enrolled and divided into the smoking group(=190)and non-smoking ngroup(=170)based on whether they smoked or not.Furthermore,the smoking group was subdivided into group A(≤n n n10 sticks/d,=63),group B(11~20 sticks/d,=80),and group C(>20 sticks/d group,=47)according to the amount of smoking.Semen volume,liquefaction time,sperm concentration,motility,DNA fragmentation rate and normal morphological rate were observed and compared between and within the groups.Results There were significant differences in semen volume,liquefaction time,sperm motility,normal morphological rate and DNA fragmentation rate between the smoking group and the non-smoking group(P<0.05).The semen volume,sperm motility and normal morphological rate of the smoking group were lower than those in the non-smoking group,and the DNA fragmentation rate and semen liquefaction time were higher than those in the non-smoking group.And with the increase of smoking volume,sperm motility and normal morphological rate decreased,semen liquefaction time and DNA fragmentation rate increased,and there was no significant difference in the sperm concentration between the smoking group and non-smoking group(P>0.05).There was no significant difference in the semen volume between the three groups with different smoking amounts(P>0.05).Conclusion Smoking has a negative impact on the sperm quality parameters such as semen volume,sperm motility,normal morphological rate,sperm motility,liquefaction time and DNA fragmentation,and the effect of heavy smoking is particularly obvious.We should strengthen the comprehensive health education,promote the healthy lifestyles and reduce smoking.

关 键 词：吸烟 男性不育 精子质量 

分 类 号：R698.2[医药卫生—泌尿科学]