运动锻炼对造血干细胞移植患者身体功能和生活质量影响的Meta分析  

Effects of exercise on physical function and quality of life in patients with Hematopoietic Stem Cell Transplant:a Metaanalysis

作　　者：张清 倪志红[2] 姚文英[2] 周雪梅[1] ZHANG Qing;NI Zhihong;YAO Wenying;ZHOU Xuemei(Department of Hematology,Children's Hospital of Soochow University,Suzhou,Jiangsu province,215025,China)

机构地区：[1]苏州大学附属儿童医院血液科,江苏省苏州市215025 [2]苏州大学附属儿童医院护理部

出　　处：《中国护理管理》2024年第1期102-108,共7页Chinese Nursing Management

基　　金：苏州市“科教兴卫”青年科技项目(KJXW202024);苏州市科技发展计划项目(SKY202048)。

摘　　要：目的 :通过Meta分析评价运动锻炼对造血干细胞移植患者身体功能和生活质量的影响,为制定有效的造血干细胞移植患者运动方案提供参考。方法 :系统检索中英文数据库中有关运动锻炼对造血干细胞移植患者影响的随机对照试验,检索时限为建库至2022年12月,2名研究员独立筛选文献、提取资料并评价文献质量,采用ReviewManager 5.3软件进行Meta分析。结果 :共纳入13篇文献,Meta分析结果显示,运动锻炼能够增加造血干细胞移植患者6分钟步行距离[MD=35.36,95%CI(16.91,55.80),P<0.001],提高生活质量[SMD=0.29,95%CI(0.14,0.44),P<0.001],但在改善峰值摄氧量[SMD=0.42,95%CI(-0.12,0.95),P=0.13]和握力[SMD=0.10,95%CI(-0.08,0.29),P=0.26]方面,差异无统计学意义。结论 :运动锻炼能够有效提高造血干细胞移植患者的心肺功能,提升生活质量,但在改善有氧代谢能力和上肢肌肉力量方面的效果尚未明确,未来需要更多高质量研究加以论证。Objective:To summarize the effects of exercise on physical function and quality of life of patients with Hematopoietic Stem Cell Transplantation(HSCT)with a meta-analysis,so as to provide a reference for formulating an effective exercise program for patients with HSCT.Methods:Randomized controlled trials on the effects of exercise on patients with HSCT were systematically searched from 9 databases in Chinese or English,and the time was from the establishment of the database to December 2022.Two researchers independently screened the literature,extracted data and evaluated the quality of the literature,and the Review Manager 5.3 software was used for meta-analysis.Results:A total of 13 studies were included,and the results of meta-analysis showed that exercise could increase 6-minute walking distance[MD=35.36,95%CI(16.91,55.80),P<0.001],improve quality of life[SMD=0.29,95%CI(0.14,0.44),P<0.001],while there was no effects in improving peak oxygen uptake[SMD=0.42,95%CI(-0.12,0.95),P=0.13]and hand grip[SMD=0.10,95%CI(-0.08,0.29),P=0.26].Conclusions:Exercise can effectively improve the cardiopulmonary function and quality of life of patients with HSCT,but on effects on improving aerobic metabolism and upper limb muscle strength,and more high-quality studies are needed to demonstrate the results in the future.

关 键 词：运动 造血干细胞移植 身体功能 生活质量 META分析 

分 类 号：R47[医药卫生—护理学] R197[医药卫生—临床医学] R457.7