血清MMP-9、sTREM-1对输尿管结石患者术后泌尿系统感染的预测价值  

The predictive value of serum MMP-9 and sTREM-1 in postoperative urinary tract infection in patients with ureteral calculi

作　　者：苍姗 张帆[2] 陶佳[1] CANG Shan;ZHANG Fan;TAO Jia(Department of Anesthesia and Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu 210000,China;Department of Urology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu 210000,China)

机构地区：[1]南京大学医学院附属鼓楼医院麻醉手术科,江苏南京210000 [2]南京大学医学院附属鼓楼医院泌尿外科,江苏南京210000

出　　处：《国际检验医学杂志》2024年第3期257-260,265,共5页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81901136)。

摘　　要：目的探讨血清基质金属蛋白酶9(MMP-9)、可溶性髓系细胞触发受体-1(sTREM-1)对输尿管结石患者术后泌尿系统感染(UTI)的预测价值。方法选取2021年10月至2022年10月在该院泌尿外科收治的输尿管结石患者中术后发生UTI的68例患者(UTI组)和未发生UTI的68例患者(非UTI组)作为研究对象。采用酶联免疫吸附试验(ELISA)检测血清MMP-9、sTREM-1水平。采用Spearman法分析UTI组血清MMP-9、sTREM-1水平与临床资料的相关性,受试者工作特征曲线分析血清MMP-9、sTREM-1水平对输尿管结石患者术后UTI的预测价值,以及多因素Logistic回归分析输尿管结石患者术后UTI发生的影响因素。结果与非UTI组相比,UTI组血清MMP-9、sTREM-1水平显著升高,差异有统计学意义(P<0.05)。相关性分析发现,UTI组患者血清MMP-9和sTREM-1水平呈正相关(r=0.585,P<0.001)。二者联合预测输尿管结石患者术后UTI的曲线下面积(AUC)为0.961(95%CI:0.934~0.988),其灵敏度、特异度分别为73.36%和85.68%,二者联合预测的AUC高于MMP-9和sTREM-1单独预测的AUC(Z=25.420,P<0.001;Z=21.531,P<0.001)。MMP-9、sTREM-1水平是输尿管结石患者术后UTI发生的影响因素(P<0.05)。结论输尿管结石术后UTI患者血清MMP-9、sTREM-1水平升高,二者水平检测对输尿管结石患者术后UTI的发生具有重要预测价值。Objective To investigate the predictive value of serum matrix metalloproteinase-9(MMP-9)and soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in postoperative urinary tract infection(UTI)in patients with ureteral calculi.Methods Among the ureteral calculi patients admitted to the Department of Urology in a hospital from October 2021 to October 2022,68 patients with postoperative UTI(UTI group)and 68 patients without UTI(non-UTI group)were selected as the study objects.Serum MMP-9 and sTREM-1 levels were detected by enzyme-linked immunosorbent assay(ELISA).Spearman method was used to analyze the correlation between serum MMP-9 and sTREM-1 levels and clinical data in UTI group,and the predictive value of serum MMP-9 and sTREM-1 levels in postoperative UTI in ureteral calculi patients was analyzed by receiver operating characteristic curve.The influencing factors of postoperative UTI in ureteral calculi patients were analyzed by multivariate Logistic regression.Results Compared with non-UTI group,serum MMP-9 and sTREM-1 levels in UTI group were significantly increased,with statistical significance(P<0.05).Correlation analysis showed that serum MMP-9 and sTREM-1 levels were positively correlated in UTI group(r=0.585,P<0.001).The combined prediction of the area under the curve(AUC)for postoperative UTI in ureteral calculi patients was 0.961(95%CI:0.934-0.988).The sensitivity and specificity were 73.36%and 85.68%,respectively.The AUC predicted by MMP-9 and sTREM-1 was higher than that predicted by MMP-9 and STREM-1 alone(Z=25.420,P<0.001;Z=21.531,P<0.001).The levels of MMP-9 and sTREM-1 were the influencing factors of postoperative UTI in ureteral calculi patients(P<0.05).Conclusion The serum levels of MMP-9 and sTREM-1 in postoperative UTI in ureteral calculi patients are increased,and the detection of both levels has important predictive value for the occurrence of postoperative UTI in ureteral calculi patients.

关 键 词：输尿管结石 基质金属蛋白酶9 可溶性髓系细胞触发受体-1 泌尿系统感染 

分 类 号：R693.4[医药卫生—泌尿科学]