血清CXCL16、ANCA水平在变应性鼻炎中的变化及其临床意义  

Changes of serum CXCL16 and ANCA levels in allergic rhinitis and their clinical significance

作　　者：张玉杰[1] 李佳慧 司宇光 ZHANG Yujie;LI Jiahui;SI Yuguang(Department of Otolaryngology,Huairou District Traditional Chinese Medicine Hospital,Beijing 101400,China;Department of General Surgery,Huairou District Traditional Chinese Medicine Hospital,Beijing 101400,China)

机构地区：[1]北京市怀柔区中医医院耳鼻喉科,北京101400 [2]北京市怀柔区中医医院普外科,北京101400

出　　处：《国际检验医学杂志》2024年第3期330-334,共5页International Journal of Laboratory Medicine

基　　金：中国管理科学研究院教育科学研究所科教创新研究重点课题(KJCX23669)。

摘　　要：目的探讨变应性鼻炎患者血清CXC趋化因子配体16(CXCL16)、抗中性粒细胞胞质抗体(ANCA)水平变化及其临床诊断价值。方法选取2022年1—12月在该院就诊治疗的变应性鼻炎患者84例(变应性鼻炎组)作为研究对象,根据其病情严重程度将其分为轻度组44例和中重度组40例,另选取同期在该院体检的健康者80例作为对照组。采用酶联免疫吸附试验法测定血清CXCL16、ANCA水平。采用Pearson分析血清CXCL16、ANCA水平与炎症因子[白细胞介素(IL)-4、IL-9、IL-13]和免疫球蛋白E(IgE)相关性。通过受试者工作特征(ROC)曲线评价血清CXCL16、ANCA水平在诊断中重度变应性鼻炎患者中的价值。结果与对照组比较,变应性鼻炎组IL-4、IL-9、IL-13和IgE水平均显著上升,差异有统计学意义(P<0.05)。与对照组比较,变应性鼻炎组血清CXCL16和ANCA水平均显著上升,差异有统计学意义(P<0.05)。血清CXCL16、ANCA水平诊断研究对象为变应性鼻炎患者的曲线下面积(AUC)分别为0.897、0.844,二者联合诊断的AUC为0.959,均优于其各自单独诊断(Z=2.164、3.474,P<0.05),特异度为93.75%,灵敏度为89.29%;变应性鼻炎患者血清CXCL16、ANCA水平均随患者病情严重程度加重而升高(P<0.05);Pearson相关分析显示,变应性鼻炎患者血清CXCL16、ANCA水平与IL-4、IL-9、IL-13及IgE均呈正相关(P<0.05);ROC曲线分析结果显示,血清CXCL16、ANCA诊断中重度变应性鼻炎患者的AUC分别为0.862、0.832,二者联合诊断的AUC为0.949,均优于其各自单独诊断(Z=1.981、2.378,P<0.05),特异度为90.91%,灵敏度为90.00%。结论变应性鼻炎患者血清CXCL16、ANCA水平均显著上升,且随患者病情严重程度加重而升高,二者在临床诊断变应性鼻炎中具有一定价值。Objective To investigate the levels of serum CXC-chemokine ligand 16(CXCL16)and anti-neutrophil cytoplasmic antibody(ANCA)in patients with allergic rhinitis and their clinical diagnostic value.Methods A total of 84 patients with allergic rhinitis(allergic rhinitis group)treated in the hospital from January to December 2022 were selected as the study objects,and were divided into mild group(44 cases)and moderate and severe group(40 cases)according to the severity of their disease.Another 80 healthy subjects who had physical examination in the same period were selected as the control group.The levels of CXCL16 and ANCA in serum were determined by enzyme-linked immunosorbent assay.The correlation between serum CXCL16 and ANCA levels and inflammatory factors[interleukin(IL)-4,IL-9,IL-13]and immunoglobulin E(IgE)was analyzed by Pearson.The value of serum CXCL16 and ANCA levels in the diagnosis of moderate and severe allergic rhinitis was evaluated by receiver operating characteristic(ROC)curve.Results Compared with control group,the levels of IL-4,IL-9,IL-13 and IgE in allergic rhinitis group were significantly increased,and the difference was statistically significant(P<0.05).Compared with control group,serum CXCL16 and ANCA levels in allergic rhinitis group were significantly increased,and the differences were statistically significant(P<0.05).The area under the curve(AUC)of serum CXCL16 and ANCA in patients with allergic rhinitis was 0.897 and 0.844,respectively.The AUC of combined diagnosis was 0.959,both of which were better than that of individual diagnosis(Z=2.164,3.474,P<0.05),and the specificity was 93.75%.The sensitivity was 89.29%.The levels of serum CXCL16 and ANCA in patients with allergic rhinitis increased with the severity of the disease(P<0.05).Pearson correlation analysis showed that serum CXCL16 and ANCA levels were positively correlated with IL-4,IL-9,IL-13 and IgE in patients with allergic rhinitis(P<0.05).ROC curve analysis results showed that the AUC of the patients diagnosed with moderate and s

关 键 词：变应性鼻炎 CXC趋化因子配体16 抗中性粒细胞胞质抗体 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]