胶原蛋白敷料在创面修复中应用的研究进展  

Research progress in the application of collagen-based dressings in wound repair

作　　者：程宇欣 张伟[2] 孔维诗 孙瑜 Cheng Yuxin;Zhang Wei;Kong Weishi;Sun Yu(Department of Radiology,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;Department of Burn Surgery,First Affiliated Hospital of Naval Medical University,Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury,Chinese Academy of Medical Sciences,Shanghai 200433,China)

机构地区：[1]海军军医大学第二附属医院放射诊断科,上海200003 [2]海军军医大学第一附属医院烧伤外科中国医学科学院烧伤暨烧创复合伤救治关键技术创新单元,上海200433

出　　处：《中华损伤与修复杂志（电子版）》2024年第1期73-77,共5页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家重点研发计划资助项目(2019YFA0110600、2019YFA0110602、2019YFA0110603);海军军医大学第一附属医院“234学科攀峰计划”(2019YXK037);海军军医大学第一附属医院“深蓝123”军事医学研究专项自由探索项目(2020SLZ009)。

摘　　要：胶原蛋白有免疫原性低、生物相容性好和可降解的特点,基于胶原蛋白的生物敷料可通过促进皮肤中多种细胞的增殖、分化和分泌,加速细胞外基质形成和重塑,进而促进创面愈合。此外,胶原蛋白敷料可吸收伤口渗出液,保持湿润的环境,同时可屏蔽机械性损伤,预防继发性细菌感染,符合理想敷料的特点,在创面管理中广泛应用。本文概述了多种胶原蛋白敷料的特点及其在创面修复中的应用进展,以期为胶原蛋白敷料的进一步研发和应用提供参考。Collagen has the excellent characteristics of low immunogenicity,good biocompatibility and biodegradability.Collagenbased biomaterials can accelerate the formation and remodeling of extracellular matrix by promoting the proliferation,differentiation and secretion of various cells in the skin,thus promoting wound healing.In addition,they can absorb wound exudate,maintain a moist environment,shield mechanical damage,and prevent secondary bacterial infections,conforming to the requirement of ideal dressings.Thus,they are widely used in wound management.In this article the characteristics of various collagenbased dressings and their application progress in wound repair were generally reviewed to provide references for further research and application of collagenbased dressings.

关 键 词：胶原蛋白 生物敷料 创面修复 伤口愈合 

分 类 号：R641[医药卫生—外科学]