纤维连接蛋白^(1-5)FNⅠ结构特性及其在周围神经损伤修复中的应用前景  

Structural characteristics of fibronectin^(1-5)FNⅠand its clinical application in the repair of peripheral nerve injury

作　　者：刘晓旭 杨晨瑗 温树正[2] 王继宏[2] 腾和 景尚斐[2] Liu Xiaoxu;Yang Chenyuan;Wen Shuzheng;Wang Jihong;Teng He;Jing Shangfei(Inner Mongolia Medical University,Hohhot 010107,China;Department of Handfoot Microsurgery,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010090,China;Department of Imaging,Inner Mongolia Hospital,Peking University Cancer Hospital,Hohhot 010013,China)

机构地区：[1]内蒙古医科大学,呼和浩特010107 [2]内蒙古医科大学第二附属医院手足显微外科,呼和浩特010090 [3]北京大学肿瘤医院内蒙古医院影像,呼和浩特010013

出　　处：《中华损伤与修复杂志（电子版）》2024年第1期87-91,共5页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：2023年内蒙古自然科学基金(2023LHMS03006);2021年内蒙古医科大学联合项目(YKD2021LH024)。

摘　　要：纤维连接蛋白Ⅰ型结构模块1-5(^(1-5)FNⅠ)具有多种细胞外基质分子识别结合位点,在细胞粘附、迁移等生理过程中发挥重要作用。本文通过^(1-5)FNⅠ位置与结构及其与细胞外基质分子的相互作用进行综述,旨在对^(1-5)FNⅠ在周围神经损伤修复再生过程中的应用前景进行初步探讨。Fibronectin type I structural module 1-5(^(1-5)FNⅠ)has a variety of extracellular matrix molecule recognition and binding sites,and plays a role in physiological processes,such as cell adhesion and migration.In this paper,the position and structure of^(1-5)FNⅠand its interaction with extracellular matrix molecules are reviewed,and the application prospect of^(1-5)FNⅠin the repair and regeneration of peripheral nerve injury is discussed.

关 键 词：纤维连接蛋白Ⅰ型结构模块1-5 结合位点 整合素 周围神经损伤 

分 类 号：R64[医药卫生—外科学]