依达拉奉右莰醇和丁苯酞联合高压氧疗对缺血性脑卒中的疗效研究  

Rapeutic effect of edaravone dexcamphorol butylphthalein combined with hyperbaric oxygen therapy on ischemic stroke

作　　者：黄伟 张强 毕天姿 刘泽民[1] HUANG Wei;ZHANG Qiang;BI Tianzi;LIU Zemin(Department of Neurology,Tangshan People's Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山市人民医院神经内一科,063000

出　　处：《中国煤炭工业医学杂志》2023年第6期603-607,共5页Chinese Journal of Coal Industry Medicine

基　　金：2019年度河北省医学科学研究课题计划(编号:20191594)。

摘　　要：目的探讨依达拉奉右莰醇和丁苯酞联合高压氧疗对缺血性脑卒中的临床疗效研究。方法选取该院神内一科2020年1月—2021年1月收治的急性脑梗塞患者88例,通过随机数字表法分为对照组43例(给予依达拉奉右莰醇和丁苯酞对症治疗)和观察组45例(给予依达拉奉右莰醇和丁苯酞对症治疗,并在此基础上同时进行高压氧疗治疗)。对观察组和对照组的疗效进行比较,检测二组患者治疗前及治疗2周后炎性反应指标(白细胞介素IL-2和白细胞介素IL-6)以及血同型半胱氨酸水平,对二组患者治疗前和治疗2周后的神经功能缺损应用美国国立卫生研究院卒中量表(NIHSS)评分进行评估及比较。结果治疗前二组炎性反应指标(白细胞介素IL-2和白细胞介素IL-6)、血同型半胱氨酸水平及神经功能缺损NIHSS评分比较,差异均无统计学意义(P>0.05),治疗2周后观察组炎性反应指标(白细胞介素IL-2和白细胞介素IL-6)、血同型半胱氨酸水平及神经功能缺损NIHSS评分均明显低于对照组,差异均有统计学意义(P<0.05)。结论依达拉奉右莰醇和丁苯酞联合高压氧疗对缺血性脑卒中患者疗效明确,不仅可以降低炎性因子表达、减轻炎症反应,而且能降低血同型半胱氨酸水平,从而达到改善患者神经功能、提高患者生活水平的目的。Objective To study the clinical effect of edaravone dexcamphorol and butylphthalein combined with hyperbaric oxygen therapy on ischemic stroke.Methods A total of eighty-eight patients with acute cerebral infarction admitted from January 2020 to January 2021 were selected and divided into control group(forty-three cases were treated with edaravone dexcamphorol and butylphthalide)and observation group(forty-five cases were treated with Edaravone dexcamphorol and butylphthalide,and on the basis of hyperbaric oxygen therapy)by random number table method and observation group.The therapeutic efficacy of the observation group and the control group were compared.Inflammatory response indicators(interleukin IL-2 and interleukin IL-6)and blood homocysteine levels were detected before and two weeks after treatment in the two groups.Neurological impairment after two weeks of treatment was evaluated and compared between the two groups using the National Institutes of Health Stroke Scale(NIHSS)score.Results There were no significant differences in inflammatory response index(interleukin IL-2 and interleukin IL-6),blood homocysteine level and NIHSS score of neurological impairment between the two groups before treatment(P>0.05).After 2 weeks of treatment,inflammatory response indexes(interleukin IL-2 and interleukin IL-6),blood homocysteine level and NIHSS score of neurological impairment in observation group were significantly lower than those in control group,with statistical significance(P<0.05).Conclusion Edaravone dexcamphorol and butylphthalein combined with hyperbaric oxygen therapy has a clear therapeutic effect on patients with ischemic stroke,which can not only reduce the expression of inflammatory factors,reduce inflammatory response,but also reduce blood homocysteine level,so as to improve the neurological function of patients and improve the living standard of patients.

关 键 词：缺血性脑卒中 高压氧 依达拉奉佑莰醇 细胞炎症因子 血同型半胱氨酸 

分 类 号：R541[医药卫生—心血管疾病]