阿利沙坦酯治疗轻中度老年高血压病的效果及对靶器官的保护作用  

Effect of allisartan isoproxil in treatment of elderly patients with mild-to-moderate hypertension and its influence on blood pressure control compliance rate and target organ protection

作　　者：周从良[1] 李亚俊 张小花[1] ZHOU Congliang;LI Yajun;ZHANG Xiaohua(Chengdu Fifth People's Hospital,Chengdu 611130,China)

机构地区：[1]四川省成都市第五人民医院,611130

出　　处：《中国煤炭工业医学杂志》2023年第6期640-645,共6页Chinese Journal of Coal Industry Medicine

基　　金：四川省卫生健康科研项目(编号:20PJ214)。

摘　　要：目的探讨阿利沙坦酯治疗轻中度老年高血压患者的效果及对血压控制达标率、靶器官的保护作用。方法对2021年1月—2022年3月成都市第五人民医院收治的120例轻中度老年高血压患者进行研究,按随机数字表法将所有患者分成对照组(n=60,氯沙坦钾治疗)和观察组(n=60,阿利沙坦酯治疗),共治疗12个月。比较二组患者治疗效果,血压变化,观察二组患者治疗前后血压变异性、靶器官指标水平,记录二组患者不良反应情况。结果观察组和对照组治疗总有效率分别为95.00%和83.33%,差异有统计学意义(P<0.05);观察组收缩压(SBP)和舒张压(DBP)平均降压幅度、SBP谷峰比值(T/P)、血压达标率均显著高于对照组(P<0.05);治疗后二组患者24h平均SBP标准差(24hSBPSD)、24h平均DBP标准差(24hDBPSD)、白昼平均SBP标准差(dSBPSD)、夜间平均SBP标准差(nSBPSD)、白昼平均DBP标准差(dDBPSD)、夜间平均DBP标准差(nDBPSD)水平、靶器官指标颈动脉内膜中层厚度(IMT)、左室质量指数(LVMI)、24h尿微量白蛋白(MA)均显著降低(P<0.05),且观察组上述指标均低于对照组(P<0.05),二组患者内生肌酐清除率(Ccr)水平显著增加(P<0.05),且观察组高于对照组(P<0.05);对照组和观察组不良反应总发生率分别为8.33%和5.01%,差异无统计学意义(P>0.05)结论阿利沙坦酯治疗轻中度老年高血压患者疗效显著,可有效改善血压变化及血压变异性,加强对靶器官保护,安全有效,适合临床推广应用。Objective To explore the effect of allisartan isoproxil in treating elderly patients with mild-to-moderate hypertension and its influence on the blood pressure control compliance rate and target organ protection.Methods One hundred and twenty elderly patients with mild-to-moderate hypertension admitted to Chengdu Fifth People's Hospital from January 2021 to March 2022 were studied and divided into control group(n=60,odd number,losartan potassium treatment)and experimental group(n=60,even number,allisartan isoproxil treatment)according to the odd-even number method,and both groups were treated for 12 months.The therapeutic effect and blood pressure changes were compared between the two groups,and the blood pressure variability and target organ indicators in the two groups were observed before and after treatment,and the adverse reactions were recorded in both groups.Results The total effective rates of treatment in experimental group and control group were 95.00% and 83.33% respectively(P<0.05).The average pressure reduction amplitudes,SBP trough-to-peak ratios(T/P)and blood pressure compliance rates of systolic blood pressure(SBP)and diastolic blood pressure(DBP)in experimental group were significantly higher than those in control group(P<0.05).After treatment,the standard deviation of 24 h mean SBP(24 h SBPSD),standard deviation of 24 h mean DBP(24 h DBPSD),standard deviation of mean daytime SBP(dSBPSD),standard deviation of mean nighttime SBP(nSBPSD),standard deviation of mean daytime DBP(dDBPSD),standard deviation of mean nighttime DBP(nDBPSD)and target organ indicators of carotid intima-media thickness(IMT),left ventricular mass index(LVMI)and 24 h urinary microalbumin(MA)were significantly decreased in both groups(P<0.05),and the above indicators in experimental groups were lower than those in control group(P<0.05),and the endogenous creatinine clearance rate(Ccr)in both groups was significantly increased(P<0.05),and the indicator was higher in experimental group than that in control group(P<0.05).The total

关 键 词：阿利沙坦酯 轻中度老年高血压 血压控制达标率 靶器官保护 

分 类 号：R544.1[医药卫生—心血管疾病]