交替温针灸联合鼠神经生长因子治疗急性期特发性面神经麻痹患者的疗效及对其面神经功能的影响  

Clinical Efficacy of Alternating Warm Needle Acupuncture Combined with Nerve Growth Factor from Rats in the Treatment of Patients with Acute Idiopathic Facial Paralysis and Its Impact on Facial Nerve Function

作　　者：汤铖 何杰[1] 江永桂[1] 唐森[1] 周大平[1] TANG Cheng;HE Jie;JIANG Yong-gui;TANG Sen;ZHOU Da-ping(The First Affiliated Hospital of Hunan Traditional Chinese Medical College(Hunan Provincial Directly Affiliated TCM Hospital),Hunan Zhuzhou 412000)

机构地区：[1]湖南中医药高等专科学校附属第一医院,湖南省直中医医院,湖南株洲412000

出　　处：《世界中西医结合杂志》2024年第1期111-115,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：湖南省中医药科研计划项目(201877)。

摘　　要：目的观察交替温针灸联合鼠神经生长因子治疗急性期特发性面神经麻痹患者的临床疗效及对其面神经功能的影响。方法选取2018年12月—2022年12月期间湖南中医药高等专科学校附属第一医院收治的86例急性期特发性面神经麻痹患者纳入研究,按随机数字表法将其分为观察组43例和对照组43例。观察组给予交替温针灸联合鼠神经生长因子治疗,对照组给予鼠神经生长因子治疗。治疗1个月后,观察比较两组患者临床疗效、不良反应情况,治疗前及治疗1个月后中医症状积分、面神经功能评分及面部神经肌电图指标[瞬目反射(RI)潜伏期、复合肌肉动作电位(CMAP)波幅]、神经因子[胶质细胞源性神经营养因子(Glial cell derived neurotrophie factor,GDNF)、神经生长因子(Nerve growth factor,NGF)]及氧化物歧化酶(Superoxide dismutase,SOD)水平。结果治疗后观察组总有效率93.02%(40/43)明显高于对照组76.74%(33/43),差异有统计学意义(P<0.05)。治疗后两组患者中医症状积分均低于治疗前,差异有统计学意义(P<0.05);且观察组中医症状积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者面神经功能评分均高于治疗前,RI潜伏期、CMAP波幅水平均低于治疗前,差异有统计学意义(P<0.05);且观察组面神经功能评分高于对照组,RI潜伏期、CMAP波幅水平低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者GDNF、NGF、SOD水平均高于治疗前,差异有统计学意义(P<0.05);且观察组GDNF、NGF、SOD水平均高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论交替温针灸联合鼠神经生长因子对急性期特发性面神经麻痹疗效较佳,能够显著改善患者症状,提高患者面神经功能,且安全性较高,可应用于临床治疗中。Objective To observe the clinical efficacy of alternating warm needle acupuncture combined with rat nerve growth factor in the treatment of patients with acute idiopathic facial paralysis and its effect on facial nerve function.Methods A total of 86 patients with acute idiopathic facial paralysis admitted to The First Affiliated Hospital of Hunan Traditional Chinese Medical College from December 2018 to December 2022 were included in the study,and were divided into observation group(43 cases)and control group(43 cases)by random number table method.The observation group was treated with alternating warm needle acupuncture combined with rat nerve growth factor,and the control group was treated with rat nerve growth factor alone.After 1 month of treatment,the clinical efficacy,adverse reactions,traditional Chinese medicine symptom scores before and after treatment,facial nerve function scores,and facial nerve electromyography indicators(blink reflex latency,compound muscle action potential amplitude)were observed and compared between the two groups.Additionally,levels of neurotrophic factors[glial cell-derived neurotrophic factor(GDNF),nerve growth factor(NGF)]and superoxide dismutase(SOD)were measured.Results After treatment,the total effective rate of the observation group was 93.02%(40/43),significantly higher than the control group′s 76.74%(33/43),with a statistically significant difference(P<0.05).After treatment,TCM symptom scores in both groups were lower than before treatment,with a statistically significant difference(P<0.05),and TCM symptom scores in the observation group were lower than those in the control group(P<0.05).After treatment,facial nerve function scores in both groups were higher than before treatment(P<0.05),and RI latency and CMAP amplitude levels were lower than before treatment(P<0.05);facial nerve function scores in observation group were higher than control group(P<0.05),and RI latency and CMAP amplitude levels were lower than control group(P<0.05).After treatment,the levels of GDNF,NG

关 键 词：特发性面神经麻痹 交替温针灸 鼠神经生长因子 疗效 面神经功能 

分 类 号：R245.315[医药卫生—针灸推拿学] R745.12[医药卫生—中医临床基础]