龟甲健骨胶囊治疗老年骨质疏松性椎体压缩骨折的疗效及影像学评价  

Efficacy and imaging Evaluation of Guijia Jiangu Capsule in the Treatment of Senile Osteoporotic Vertebral Compression Fracture

作　　者：王柳英 杜燕 袁华均 唐鸿杰 WANG Liu-ying;DU Yan;YUAN Hua-jun;TANG Hong-jie(Department of Radiology,Nanchong Traditional Chinese Medicine Hospital,Nanchong Sichuan 637000;Orthopedics Department,Nanchong Traditional Chinese Medicine Hospital,Nanchong Sichuan 637000;Key Laboratory of Traditional Chinese medicine for prevention and treatment of skeletal muscle disease in Nanchong,Nanchong Sichuan 637000)

机构地区：[1]南充市中医医院放射影像科,四川南充637000 [2]南充市中医医院骨一科,四川南充637000 [3]筋骨病中医药防治南充市重点实验室,四川南充637000

出　　处：《世界中西医结合杂志》2024年第1期145-149,155,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：2019年市级应用技术研究与开发基金项目(19YFZJ0003)。

摘　　要：目的探讨龟甲健骨胶囊治疗老年骨质疏松性椎体压缩骨折(Osteoporotic vertebral compression fracture,OVCF)的疗效。方法选取2021年11月—2022年10月期间南充市中医医院收治的206例老年OVCF患者作为研究对象,按随机数字表法分观察组和对照组,每组各103例。两组患者均行经皮椎体成形术,对照组术后给予常规西药用药,观察组西药联合龟甲健骨胶囊。治疗3个月后,观察比较两组患者临床疗效、骨折愈合时间、并发症发生情况,手术前后病椎椎体前缘高度、椎体后缘高度及Cobb角,血清缺氧诱导因子1α(Hypoxia-inducible factor 1α,HIF-1α)、血管内皮生长因子(Vascular endothelial growth factor,VEGF)水平,骨代谢指标[碱性磷酸酶(Alkaline phosphatase,ALP)、骨钙素(Bone gamma-carboxyglutamic-acid-containing proteins,BGP)、骨密度(Bone mineral density,BMD)],Oswestry功能障碍指数(Oswestry Disability Index,ODI)评分。结果术后3个月两组患者椎体前缘高度、椎体后缘高度均较术前明显升高,Cobb角较术前明显缩小,差异有统计学意义(P<0.05);且观察组椎体前缘高度、椎体后缘高度均较对照组明显升高,差异有统计学意义(P<0.05),Cobb角与对照组接近,差异无统计学意义(P>0.05)。术后3个月两组患者血清HIF-1α、VEGF水平均较术前升高,差异有统计学意义(P<0.05);且观察组血清HIF-1α、VEGF水平均明显高于对照组,差异有统计学意义(P<0.05)。术后观察组骨折愈合时间明显短于对照组,差异有统计学意义(P<0.05)。术后3个月两组患者ALP、BGP、BMD水平均较术前升高,差异有统计学意义(P<0.05);且观察组ALP、BGP、BMD水平均较对照组明显升高,差异有统计学意义(P<0.05)。术后3个月两组患者ODI评分均较术前降低,差异有统计学意义(P<0.05);且观察组ODI评分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后观察组总有效率92.23%(95/103)明显高于对照组75.73%(78/103),差异�Objective To explore the efficacy of Guijia Jiangu capsule on senile osteoporotic vertebral compression fracture(OVCF).Methods A toal of 206 elderly OVCF patients admitted to Nanchong Traditional Chinese Medicine Hospital from November 2021 to October 2022 were selected as the research subjects.They were randomly divided into an observation group and a control group using a random number table method,with 103 cases in each group,.Both groups underwent percutaneous vertebroplasty,with the control group receiving conventional Western medicine after surgery,and the observation group receiving a combination of Western medicine and Guijia Jiangu capsules.After 3 months of treatment,the clinical efficacy,fracture healing time,incidence of complications,pre and postoperative vertebral anterior and posterior heights,Cobb angle,and serum levels of hypoxia-inducible factor 1(HIF-1α),vascular endothelial growth factor(VEGF),bone metabolism indicators[alkaline phosphatase(ALP),bone gamma-carboxyglutamic-acid-containing proteins(BGP),bone mineral density(BMD)]and Oswestry Disability Index(ODI)scores were observed and compared between the two groups of patients.Results After 3 months of surgery,the vertebral anterior and posterior heights of the two groups were significantly higher than before surgery,and the Cobb angle was significantly reduced compared to before surgery,with a statistically significant difference(P<0.05).The heights of the vertebral anterior and posterior bodies in the observation group were significantly higher than that in the control group,with statistical significance(P<0.05).The Cobb angle was similar to that in the control group,with no statistical significance(P>0.05).After 3 months,both groups showed a significant increase in serum HIF-1 and VEGF levels compared to before surgery(P<0.05),and the observation group's serum HIF-1αand VEGF levels were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).The fracture healing time in the postoperat

关 键 词：龟甲健骨胶囊 骨质疏松性椎体压缩骨折 骨密度 椎体成形术 骨代谢 

分 类 号：R683[医药卫生—骨科学]