阿卡波糖片与二甲双胍治疗2型糖尿病的临床效果及药物不良反应分析  

Clinical Effects and Adverse Drug Reactions of Acarbose Tablets and Metformin in the Treatment of Type 2 Diabetes Mellitus

作　　者：李剑珠 宋宏 沈燕萍 LI Jianzhu;SONG Hong;SHEN Yanping(Department of Pharmacy,the Affiliated Hospital of Putian University,Putian,Fujian Province,351100 China)

机构地区：[1]莆田学院附属医院药剂科,福建莆田351100

出　　处：《糖尿病新世界》2023年第22期77-80,共4页Diabetes New World Magazine

摘　　要：目的探究阿卡波糖片与二甲双胍治疗2型糖尿病(diabetes mellitus type 2,T2DM)的临床效果及药物不良反应分析。方法选取2020年10月—2022年10月于莆田市荔城区莆田学院附属医院进行治疗的86例T2DM患者作为研究对象,采用信封法随机分为二甲双胍组与阿卡波糖片组,每组43例,分别予以二甲双胍与阿卡波糖片治疗。比较两组血糖水平、不良反应发生情况以及生活质量。结果治疗后,阿卡波糖片组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于二甲双胍组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,阿卡波糖片组世界卫生组织生活质量测定简表中的躯体、社会、环境、心理、综合维度评分均高于二甲双胍组,差异有统计学意义(P<0.05)。结论针对T2DM患者,阿卡波糖片与二甲双胍疗效确切,安全性相当,但阿卡波糖片相对能更好地控制患者血糖,患者的生活质量更高。Objective To explore the clinical effects and adverse drug reactions of Acarbose tablets and Metformin in the treatment of type 2 diabetes mellitus(T2DM).Methods A total of 86 T2DM patients treated in the Affiliated Hospital of Putian University,Licheng District,Putian City from October 2020 to October 2022 were selected as the study objects.They were randomly divided into Metformin group and Acarbose tablet group by envelope method,with 43 cases in each group receiving Metformin andAcarbose tablet treatment,respectively.Blood glucose levels,adverse reactions and quality of life were compared between the two groups.Results After treatment,fasting blood glucose,2 hours postprandial blood glucose and glycated hemoglobin levels in Acarbose tablet group were lower than those in Metformin group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the scores of physical,social,environmental,psychological and comprehensive dimensions of Acarbose tablet group were higher than those of Metformin group,and the differences were statistically significant(P<0.05).Conclusion For T2DM patients,Acarbose tablets have the same efficacy and safety as Metformin,but Acarbose tablets can better control patients'blood glucose and improve patients'quality of life.

关 键 词：2型糖尿病 阿卡波糖片 二甲双胍 临床效果 安全性 生活质量 

分 类 号：R587[医药卫生—内分泌]