β2-微球蛋白、尿素氮、血肌酐、胱抑素C与糖化血红蛋白联合检测在老年2型糖尿病患者肾功能检查中的效果  

Effectiveness of Combined Testing of β2-microglobulin,Urea Nitrogen,Blood Creatinine,Cystatin C and Glycated Hemoglobin in Renal Function Examination of Elderly Patients with Type 2 Diabetes Mellitus

作　　者：巫婷婷 徐媛 张才田 WU Tingting;XU Yuan;ZHANG Caitian(Department of Laboratory,Yizheng People's Hospital,Yizheng,Jiangsu Province,211400 China)

机构地区：[1]仪征市人民医院检验科,江苏仪征211400

出　　处：《系统医学》2023年第23期9-12,共4页Systems Medicine

摘　　要：目的探讨β2-微球蛋白、尿素氮、血肌酐、胱抑素C与糖化血红蛋白联合检测在老年2型糖尿病患者肾功能检查中的应用效果。方法选取2021年1月—2022年12月于江苏省仪征市人民医院就诊的118例老年2型糖尿病伴肾损伤患者作为研究组,65例老年单纯2型糖尿病患者作为对照组,另选取在本院接受接受健康体检的100例健康志愿者作为健康组。所有人测定糖化血红蛋白、β2-微球蛋白、尿素氮、血肌酐、胱抑素C水平。对比3组检查结果并作出深入分析。结果研究组糖化血红蛋白、β2-微球蛋白、尿素氮、血肌酐、胱抑素C水平分别为(8.94±1.25)%、(3.95±0.63)mg/L、(9.58±1.03)mmol/L、(126.57±17.20)μmol/L、(1.79±0.41)mg/L,均高于对照组、健康组,差异有统计学意义(P<0.05);而对照组各项指标水平均高于健康组,差异有统计学意义(P<0.05)。对于2型糖尿病伴肾损伤开展诊断时,β2-微球蛋白、尿素氮、血肌酐、胱抑素C联合检测的灵敏度、特异度、准确率、阳性预测值、阴性预测值的数值均高于各项指标单一检测,差异有统计学意义(P<0.05)。结论血清胱抑素C、肾功能指标开展联合检测具有良好的诊断价值,可提高对于2型糖尿病患者肾损伤的诊断准确性。Objective To explore the application effect of combined testing of β2-microglobulin,urea nitrogen,blood creatinine,cystatin C and glycated hemoglobin in renal function examination of elderly patients with type 2 diabetes mellitus.Methods From January 2021 to December 2022,118 elderly patients with type 2 diabetes mellitus with renal injury and 65 elderly patients with simple type 2 diabetes mellitus from Jiangsu Yizheng People's Hospital were selected as the study group and control group,and 100 healthy volunteers who received physical examination in our hospital were selected as the healthy group.All of them measured glycated hemoglobin,β2-microglobulin,urea nitrogen,blood creatinine,and cystatin C levels.The results of the three groups were compared and analyzed in depth.Results Glycated hemoglobin,β2-microglobulin,urea nitrogen,blood creatinine,and cystatin C levels in the study group were(8.94±1.25)%,(3.95±0.63)mg/L,(9.58±1.03)mmol/L,(126.57±17.20)μmol/L,and(1.79±0.41)mg/L,respectively,which were higher than those of control group and healthy group,and the differences were statistically significant(P<0.05).The levels of various indicators in the control group were higher than those in the healthy group,and the differences were statistically significant(P<0.05).When carrying out the diagnosis of type 2 diabetes mellitus with renal injury,the combined testing of β2-microglobulin,urea nitrogen,blood creatinine,and cystatin C had higher values of sensitivity,specificity,accuracy,positive predictive value,and negative predictive value than single testing for various indicators,and the differences were statistically significant(P<0.05).Conclusion The combined test of serum cystatin C and renal function indexes has good diagnostic value and can improve the diagnostic accuracy of renal injury in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病肾病 诊断 Β2-微球蛋白 尿素氮 血肌酐 胱抑素C 

分 类 号：R446.1[医药卫生—诊断学]