TyG指数、血压、血糖相关指标与单纯性超重/肥胖患者早期肾功能损伤的关系  

Relationship between TyG index,blood pressure,blood glucose related index and early renal function injury in simple overweight/obesity patients

作　　者：秦迁[1] 杨阳[1] 闫肃 闫航[1] 王守俊[3] 丁素英[1] QIN Qian;YANG Yang;YAN Su;YAN Hang;WANG Shoujun;DING Suying(Health Management Center,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Department of Epidemiology and Health Statistics,College of Public Health,Zhengzhou University,Zhengzhou 450001;Department of Endocrinology and Metabolic Diseases,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院健康管理中心,郑州450052 [2]郑州大学公共卫生学院流行病与卫生统计学教研室,郑州450001 [3]郑州大学第一附属医院内分泌与代谢病科,郑州450052

出　　处：《郑州大学学报（医学版）》2024年第1期99-103,共5页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关计划项目(222102310226);河南省医学科技攻关计划联合共建项目(LHGJ20210354)。

摘　　要：目的:探讨TyG指数、血压、血糖相关指标与单纯性超重/肥胖患者早期肾功能损伤(ERFI)的关系及交互作用。方法:选取2017年1月至2021年12月于郑州大学第一附属医院体检的BMI≥24 kg/m 2者3956例为研究对象,按尿白蛋白与肌酐比值(UACR)分组,<3 mg/mmol为对照组(n=3844),3~≤30 mg/mmol为ERFI组(n=112)。采用Logistic回归分析甘油三酯葡萄糖(TyG)指数、血压和糖化血红蛋白(HbA1c)与ERFI的关联,并进一步分析各因素的交互作用。结果:ERFI组的BMI、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、HbA1c、总胆固醇(TG)、TyG指数高于对照组,HDL-C低于对照组(P<0.05)。TyG指数>8.77(OR=2.138,95%CI:1.411~3.240)、正常血压高值(OR=2.450,95%CI:1.652~3.635)和HbA1c 5.61%~<7.00%(OR=1.510,95%CI:1.024~2.226)是单纯性超重/肥胖患者ERFI的危险因素。TyG指数与血压有交互作用(RERI=1.754,95%CI:-0.126~3.636;APAB=0.405,95%CI:0.068~0.741)。结论:TyG指数≥8.77、正常血压高值和HbA1c 5.61%~<7.00%可增加单纯性超重/肥胖患者ERFI的患病风险,且血压与TyG指数存在交互作用。Aim:To investigate the relationship and interaction of TyG index,blood pressure,blood glucose relative index related early renal function impairment(ERFI)in patients with simple overweight/obesity.Methods:A total of 3956 subjects with BMI≥24 kg/m 2 who taken physical examination from January 2017 to December 2021 in the First Affiliated Hospital,Zhengzhou University were allocated into 2 groups according to urinary albumin-to-creatinine ratio(UACR),<3 mg/mmol was the control group(n=3844),and 3~≤30 mg/mmol was the ERFI group(n=112).Logistic regression was used to analyze the relationship between TyG index,blood pressure,glycosylated hemoglobin(HbA1c)and ERFI,and the interaction of each factor was further analyzed.Results:BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting plasma glucose(FPG),HbAlc,total cholesterol(TC)and TyG index in ERFI group were higher than those in control group,and HDL-C was lower than those in control group(P<0.05).TyG index≥8.77(OR=2.138,95%CI:1.411-3.240),high-normal value of blood pressure(OR=2.450,95%CI:1.652-3.635)and HbA1c 5.61%~<7.00%(OR=1.510,95%CI:1.024-2.226)were risk factors for ERFI in patients with simple overweight/obesity.TyG index interacted with blood pressure(RERI=1.754,95%CI:-0.126-3.636;APAB=0.405,95%CI:0.068-0.741).Conclusion:TyG index≥8.77,high-normal value of blood pressure and HbA1c 5.61%~<7.00%can increase the risk of ERFI in patients with simple overweight/obesity,and there is an interaction between blood pressure and TyG index.

关 键 词：单纯性超重/肥胖 甘油三酯葡萄糖指数 早期肾功能损伤 正常血压高值 交互作用 

分 类 号：R692.5[医药卫生—泌尿科学]