吉林省部分医护健康体检人群外周血同型半胱氨酸水平与血脂的相关性分析  

Correlation analysis of homocysteine level in peripheral blood and blood lipids in some medical health check-up population in Jilin province

作　　者：颜培玉 阚英南[1] 杨宏凤[1] 吕斌[1] 田瑗[1] 邱仁娜[1] 孙晶[1] YAN Peiyu;KAN Yingnan;YANG Hongfeng;LV Bin;TIAN Yuan;QIU Renna;SUN Jing(The Health(Physical Examination)Center,The China-Japan Union Hospital of Jilin University,Changchun 130033,China)

机构地区：[1]吉林大学中日联谊医院健康管理(体检)中心,吉林长春130033

出　　处：《中国实验诊断学》2024年第1期44-50,共7页Chinese Journal of Laboratory Diagnosis

摘　　要：目的调查研究吉林省部分医护健康体检人群高同型半胱氨酸血症(Hyperhomocysteinemia,HHcy)的现状,探讨外周血同型半胱氨酸(Homocysteine,Hcy)与血脂及其各组分的关系。方法以2021年1月至2021年10月在吉林大学中日联谊医院进行健康体检的医护人群为研究对象。回顾性收集并记录问卷信息及各项指标。利用SPSS 25.0软件统计、分析医护健康体检人群HHcy的阳性率及Hcy的分布特点。采用Pearson或Spearman分析Hcy与血脂及其各组分等影响因素的相关性。采用多元逐步线性回归分析影响Hcy的主要因素。结果(1)HHcy的阳性率为59.73%,男性阳性率(87.71%)明显高于女性(50.15%)(χ^(2)=344.64,P<0.05);(2)女性HHcy组血脂异常、血清总胆固醇(Total Cholesterol,TC)及低密度脂蛋白胆固醇(Low Density Lipoprotein cholesterol,LDL-C)升高人数明显高于对照组(P<0.05);(3)女性22~39岁组和40~59岁组HHcy的阳性率明显低于60~92岁组(P<0.05);(4)血脂异常率达57.27%,男性血脂异常率(83.90%)明显高于女性(36.92%)(χ^(2)=201.21,P<0.05);(5)男性和女性医护人员Hcy均与收缩压及舒张压具有显著相关性(P<0.05);(6)女性医护人员Hcy与血脂中的TC具有相关性(P<0.05)。结论吉林省医护健康体检人群HHcy患病率较高,外周血Hcy水平存在性别差异,女性医护健康体检人群Hcy水平与血脂中的TC具有相关性。Objective To investigate the current situation of HyperHomocysteinemia(HHcy)in some health care and physical examination population in Jilin Province,and to explore the relationship between peripheral blood homocysteine(Hcy)and blood lipids and their components.Methods The medical staff who underwent physical examination at the Physical Examination Center of Sino-Japanese Friendship Hospital,Jilin University from January 2021to October 2021were selected as the subjects of the study.The questionnaire information and indicators were collected and recorded retrospectively.SPSS 25.0software was used to analyze the positive rate of HHcy and the distribution characteristics of Hcy in health care and physical examination population.Pearson’s or Spearman’s methods were used to analyze the correlation between Hcy and blood lipids,their components and other influencing factors.Multivariate stepwise linear regression was used to analyze the main factors affecting Hcy.Results(1)The positive rate of HHcy was 59.73%,and the positive rate of male(87.71%)was significantly higher than that of female(50.15%)(χ^(2)=344.64,P<0.05);(2)The number of dyslipidemia,Total Cholesterol,TC)and low density lipoprotein cholesterol(LDL-C)in female HHcy group was significantly higher than that in the control group(P<0.05);(3)The positive rate of HHcy in women aged 22-39and 40-59was significantly lower than that in women aged 60-92(P<0.05);(4)The dyslipidemia rate reached 57.27%,and the dyslipidemia rate of males(83.90%)was significantly higher than that of females(36.92%)(χ^(2)=201.21,P<0.05);(5)Hcy was significantly correlated with systolic and diastolic blood pressure in both male and female medical staff(P<0.05);(6)There was a correlation between Hcy and TC in blood lipids of female medical staff(P<0.05).Conclusion The prevalence rate of HHcy in medical and health examination population in Jilin Province was high,and there was a gender difference in peripheral blood Hcy level.The level of Hcy in female medical and health examination pop

关 键 词：高同型半胱氨酸血症 血脂及其各组分 相关性研究 影响因素 

分 类 号：R446.1[医药卫生—诊断学]