海水淹溺性急性肺损伤的致病机制及救治策略研究进展  

Research progress on pathogenic mechanism and treatment strategy of seawater induced acute lung injury

作　　者：李田飞 张灏 魏梁锋 王守森 LI Tianfei;ZHANG Hao;WEI Liangfeng;WANG Shousen(Department of Cerebral Surgery,Bozhou Hospital of Traditional Chinese Medicine,Bozhou,Anhui 236800,P.R.China;Department of Neurosurgery,the 900th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army,Fuzhou,Fujian 350025,P.R.China)

机构地区：[1]亳州市中医院脑外科,安徽亳州236800 [2]中国人民解放军联勤保障部队第九〇〇医院神经外科,福州350025

出　　处：《华西医学》2024年第1期147-152,共6页West China Medical Journal

基　　金：中国人民解放军联勤保障部队第九〇〇医院2022年度医院科研计划(2022ZL01,2022ZL03)。

摘　　要：海水淹溺导致急性肺组织结构损伤,引起肺通气和换气功能障碍,诱发急性肺水肿甚至急性呼吸衰竭。海水淹溺性急性肺损伤致病机制复杂,涉及炎性反应、肺水肿、肺泡表面活性物质、氧化应激及细胞凋亡和自噬等方面。及时有效的救治,是降低海水淹溺性急性肺损伤患者致死率和致残率的关键。该文对海水淹溺性急性肺损伤的致病机制和救治策略2个方面的研究进展进行归纳总结,旨在为临床工作中海水淹溺性急性肺损伤患者的综合救治和后续的相关研究提供参考。Seawater drowning leads to acute lung tissue structure injury,lung ventilation and air exchange dysfunction,acute pulmonary edema,and even acute respiratory failure.The pathogenesis of seawater induced acute lung injury is complex,involving inflammatory response,pulmonary edema,pulmonary surfactant,oxidative stress,apoptosis and autophagy.Timely and effective treatment is the key to reduce the mortality and disability rate of patients with seawater induced acute lung injury.This article summarizes the research progress in the pathogenic mechanism and treatment strategy of seawater induced acute lung injury,aiming to provide reference for the comprehensive treatment of seawater induced acute lung injury patients in clinical work and subsequent related research.

关 键 词：海水淹溺 肺损伤 海水淹溺性急性肺损伤 致病机制 救治策略 

分 类 号：R649.3[医药卫生—外科学]