抗菌增敏剂恢复耐药细菌对抗生素敏感性的研究进展  

Progresses of antibacterial sensitizers to restore the susceptibility of drug-resistant bacteria to antibiotics

作　　者：卢嵘 成泓 赵西林[1] 王岱[1] Lu Rong;Cheng Hong;Zhao Xiin;Wang Dai(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102)

机构地区：[1]厦门大学公共卫生学院分子疫苗和分子诊断学国家重点实验室,厦门361102

出　　处：《中国抗生素杂志》2023年第11期1201-1210,共10页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(No.81971905,No.82172316)。

摘　　要：抗生素耐药性的产生使现有抗生素的治疗不再有效,而新抗生素的开发耗时长、难度高,无法解决日益严重的耐药菌感染难题。抗菌增敏剂与抗生素联合疗法为耐药菌感染的治疗带来了希望,抗菌增敏剂能够恢复抗生素的杀菌活性,同时减缓耐药的发展进程,是对抗耐药菌有效且可持续的策略。本文概述了抗菌增敏剂的作用靶点,在此基础上简述了几种典型超级细菌的抗菌增敏剂-抗生素联合治疗策略,并对近些年抗菌增敏剂的相关研究进行了总结归纳,以期为抗菌增敏剂的进一步研究和应用提供参考。The development of antibiotic resistance has made the treatment of existing antibiotics no longer effective,while the development of new antibiotics is time-consuming and difficult to address the growing challenge of drug-resistant bacterial infections.Combination therapies of antibacterial sensitizers and antibiotics are hopeful for the treatment of drug-resistant bacterial infections.Antibacterial sensitizers can restore the bactericidal activity of antibiotics while slowing the progression of drug resistance,making them an effective and sustainable strategy against drug-resistant bacteria.This article outlines the action targets of antibacterial sensitizers,briefly describes several typical antibacterial sensitizer-antibiotic combination therapy strategies for superbugs,and summarizes the relevant research on antibacterial sensitizers in recent years,in order to provide reference for further research and application.

关 键 词：抗生素耐药性 抗菌药物增敏药 联合治疗 协同作用 

分 类 号：R978.1[医药卫生—药品]