炎症指标和血清淀粉样蛋白A联合检测在小儿急性呼吸道感染中的应用价值  

Application value of combined detection of inflammation indexes and serum amyloid A in children with acute respiratory infection

作　　者：李传利 Li Chuanli(Department of Clinical Laboratory,Shandong Yiyang Health Group Zibo Hospital,Zibo 255120,Shandong,China)

机构地区：[1]山东颐养健康集团淄博医院检验科,山东淄博255120

出　　处：《实用检验医师杂志》2023年第4期381-384,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的探讨炎症指标及血清淀粉样蛋白A(SAA)联合检测在小儿急性呼吸道感染中的应用价值。方法纳入2021年7月—2022年7月至山东颐养健康集团淄博医院就诊的120例急性呼吸道感染患儿作为观察组,另外选择同期收治的120例未感染儿童作为对照组。使用全自动化学发光测定仪,采用电化学发光定量法检测两组儿童血清降钙素原(PCT)、SAA、白细胞介素-6(IL-6)水平,采用速率散射比浊法检测C-反应蛋白(CRP)水平;使用细胞分析仪与配套试剂检测白细胞计数(WBC);分析并比较两组受检者上述指标水平以及PCT与CRP的阳性率差异。结果观察组的血清PCT、IL-6、SAA、CRP、WBC水平均明显高于对照组[PCT(μg/L):4.33±1.39比1.78±1.42,IL-6(ng/L):111.23±20.36比37.65±10.25,SAA(mg/L):163.58±5.56比9.63±1.58,CRP(mg/L):77.58±10.20比67.02±9.52,WBC(×10^(9)/L):14.20±2.58比7.36±1.85,均P<0.05]。观察组PCT与CRP的阳性率均明显高于对照组(PCT:35.00%比21.67%,CRP:84.17%比71.67%,均P<0.05)。结论加强PCT、IL-6、SAA、CRP、WBC联合检测有助于了解急性呼吸道感染患儿的病情发展,从而指导疾病治疗,临床应用价值较高。Objective To investigate the application value of combined detection of inflammation indexes and serum amyloid A(SAA)in children with acute respiratory infection.Methods A total of 120 children with acute respiratory infection who were admitted in Shandong Yiyang Health Group Zibo Hospital from July 2021 to July 2022 were included in observation group,and 120 uninfected children admitted during the same period were selected as control group.Using a fully automated chemiluminescence analyzer,the serum levels of procalcitonin(PCT),SAA and interleukin-6(IL-6)in two groups of children were detected using electrochemical luminescence quantitative method,and the level of C-reactive protein(CRP)was detected using rate scattering turbidimetry.Using a cell analyzer and matching reagents,the level of white blood cell count(WBC)was detected.The positive rates of PCT and CRP between the two groups were analyzed and compared.Results The levels of serum PCT,IL-6,SAA,CRP and WBC in the observation group were significantly higher than those in the control group[PCT(μg/L):4.33±1.39 vs.1.78±1.42,IL-6(ng/L):111.23±20.36 vs.37.65±10.25,SAA(mg/L):163.58±5.56 vs.9.63±1.58,CRP(mg/L):77.58±10.20 vs.67.02±9.52,WBC(×10^(9)/L):14.20±2.58 vs.7.36±1.85,all P<0.05].The positive rates of PCT and CRP in observation group were significantly higher than those in control group(PCT:35.00%vs.21.67%,CRP:84.17%vs.71.67%,both P<0.05).Conclusion Strengthening the combined detection of PCT,IL-6,SAA,CRP and WBC is helpful to understand the development of acute respiratory infection in children,so as to guide the treatment of the disease,and has high clinical value.

关 键 词：急性呼吸道感染 降钙素原 白细胞介素-6 血清淀粉样蛋白A C-反应蛋白 白细胞计数 

分 类 号：R725.6[医药卫生—儿科]