三子养亲汤加减联合针刺对慢性阻塞性肺疾病稳定期合并肌少症患者的临床疗效  

Clinical effects of Modified Sanzi Yangqin Decoction combined with acupuncture on patients with chronic obstructive pulmonary disease at stable stage complicated with sarcopenia

作　　者：张艳丽 宋昳星[2] 徐丹[3] ZHANG Yan-li;SONG Yi-xing;XU Dan(Department of Respiratory,Sanya Municipal Hospital of Traditional Chinese Medicine,Sanya 572000,China;Department of Acupuncture and Moxibustion,Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University,Urumqi 830011,China;National Clinical Research Base of Traditional Chinese Medicine,Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]三亚市中医院呼吸科,海南三亚572000 [2]新疆医科大学附属中医医院针灸科,新疆乌鲁木齐830011 [3]新疆医科大学附属中医医院国家中医临床研究基地,新疆乌鲁木齐830011

出　　处：《中成药》2024年第1期107-111,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(82060802)。

摘　　要：目的探讨三子养亲汤加减联合针刺对慢性阻塞性肺疾病稳定期合并肌少症患者的临床疗效。方法94例患者随机分为对照组和观察组,每组47例,对照组给予常规治疗,观察组在对照组基础上加用三子养亲汤加减联合循经针刺,疗程8周。检测临床疗效、中医证候评分、肺功能指标(FVC、FEV1、FEV1/FVC)、炎症因子(CRP、IL-6、TNF-α),肌肉特异性生物标志物(MSTN、IGF-1)、相关量表评分(SARC-F、SPPB)、骨骼肌质量指数变化。结果观察组总有效率高于对照组(P<0.05)。治疗后。2组中医证候评分、炎症因子、MSTN、SARC-F评分降低(P<0.05),肺功能指标、IGF-1、SPPB评分、骨骼肌质量指数升高(P<0.05),以观察组更明显(P<0.05)。结论三子养亲汤加减联合针刺对慢性阻塞性肺疾病稳定期合并肌少症患者临床疗效显著。AIM To explore the clinical effects of Modified Sanzi Yangqin Decoction combined with acupuncture on patients with chronic obstructive pulmonary disease at stable stage complicated with sarcopenia.METHODS Ninety-four patients were randomly assigned into control group(47 cases)for 8-week intervention of conventional treatment,and observation group(47 cases)for 8-week intervention of Modified Sanzi Yangqin Decoction,acupuncture and conventional treatment.The changes in clinical effects,TCM syndrome scores,and levels of pulmonary function indices(FVC,FEV1,FEV1/FVC),inflammatory factors(CRP,IL-6,TNF-α),muscle-specific biomarkers(MSTN,IGF-1),relevant scale scores(SARC-F,SPPB)and skeletal muscle mass index were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,inflammatory factors,MSTN,SARC-F score(P<0.05),and increased pulmonary function indices,IGF-1,SPPB score,skeletal muscle mass index(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with chronic obstructive pulmonary disease at stable stage complicated with sarcopenia,Modified Sanzi Yangqin Decoction combined with acupuncture exhibits significant clinical efficacy.

关 键 词：三子养亲汤 针刺 常规治疗 慢性阻塞性肺疾病稳定期 肌少症 

分 类 号：R287[医药卫生—中药学]