Sortilin促进心血管疾病的研究进展  

Research advances of Sortilin in cardiovascular diseases

作　　者：李慧娟 刘芳 陈诗芮 明新月 吕运成 LI Huijuan;LIU Fang;CHEN Shirui;MING Xinyue;LYU Yuncheng(Guangxi Key Laboratory of Diabetic Systems Medicine/Institute of Basic Medical Sciences,School of Basic Medicine,Guilin Medical University,Guilin 541199,China)

机构地区：[1]桂林医学院基础医学院广西糖尿病系统医学重点实验室/基础医学研究所,广西桂林541199

出　　处：《华夏医学》2023年第5期7-15,共9页Acta Medicinae Sinica

基　　金：国家自然科学基金项目(82160098);广西自然科学基金项目(2019JJA140728)。

摘　　要：Sortilin是由人SORT1基因编码的分拣蛋白,分选、运输细胞内相关蛋白底物。Sortilin不仅参与脂蛋白代谢升高血脂促进巨噬细胞内脂质蓄积与泡沫细胞形成,而且通过调控细胞因子分泌及免疫细胞间相互作用促进炎症反应。Sortilin经翻译后修饰及其介导细胞分化还可促进血管壁及瓣膜钙化。此外,Sortilin调控鞘磷脂代谢相关酶的胞内运输促进氧化应激。Sortilin主要通过增加内皮氧化应激损害血管舒缩功能导致高血压,还可通过促进动脉内皮下脂质蓄积、炎性细胞浸润及动脉壁钙盐沉着促进动脉粥样硬化性心血管疾病,并且能通过促进外周血管钙化与糖脂代谢紊乱引发微循环障碍,进而促进糖尿病外周血管疾病。总之,Sortilin在心血管疾病的发生发展中发挥重要致病作用,并具备潜在干预价值。Sortilin,a sorting protein encoded by the human gene SORT1,can select and transport cellular substrate proteins.Sortilin not only participates in lipoprotein metabolism,which elevates blood lipids and promotes lipid accumulation and foam cell formation within macrophages,but also modulates the secretion of cytokines and the interaction between immune cells to promote inflammatory response.The epigenetically modified Sortilin⁃mediated differentiation of cells can facilitate the calcification of vessel walls and valves.In addition,Sortilin⁃transported enzymes have related to sphingolipid metabolism to ignite intracellular oxidative stress.The capacity of arterial vasomotoricity mainly eroded by Sortilin⁃aroused endothelial oxidative stress,ultimately caused the occurrence of hypertension.The development of atherosclerotic cardiovascular disease is impelled by Sortilin⁃promoted aortic lipid deposition,inflammatory infiltration and calcareous deposit in subendothelial space.Furthermore,Sortilin⁃boosted calcification of peripheral vascular and Sortilin⁃elicited disorders of glycolipid metabolism have triggered microcirculation disorders,leading to the progression of peripheral vascular complications of diabetes.In conclusion,Sortilin plays a crucial role in the processes of cardiovascular diseases,and is the potential value of therapeutic intervention.

关 键 词：SORTILIN 高血压 动脉粥样硬化性心血管疾病 糖尿病外周血管疾病 

分 类 号：R54[医药卫生—心血管疾病]