反复呼吸道感染患儿血清微量元素含量与免疫功能的相关性分析  

Correlation analysis between serum trace elements and immune function in children with recurrent respiratory tract infection

作　　者：张肖肖 岳辉 ZHANG Xiaoxiao;YUE Hui(Puyang Huimin Hospital,Puyang 457000,China)

机构地区：[1]濮阳惠民医院,河南濮阳457000

出　　处：《华夏医学》2023年第5期69-73,共5页Acta Medicinae Sinica

基　　金：河南省医学科技攻关计划项目(LHGJ20191803)。

摘　　要：目的:分析反复呼吸道感染(RRTI)患儿血清微量元素含量与免疫功能的相关性。方法:选取120例RRTI患儿作为研究组,另选择同期进行体检的60例健康儿童作为对照组。统一抽取两组儿童外周血,采用原子吸收光谱分析法测量血清微量元素含量,采用T淋巴细胞计数仪检测外周血T细胞亚群水平,对比两组差异并分析RRTI患儿血清微量元素与免疫功能的相关性。结果:研究组血清微量元素水平及外周血T细胞亚群均低于对照组,CD8^(+)水平高于对照组,差异均具有统计学意义(P<0.05)。而Ca、Zn、Fe、Cu水平及CD4^(+)、CD4^(+)/CD8^(+)水平与小儿RRTI均呈负相关(r=-0.723~-0.582,P<0.05),CD8^(+)水平与小儿RRTI呈正相关(r=0.659,P<0.05)。Ca、Zn、Fe、Cu水平与CD4^(+)、CD4^(+)/CD8^(+)水平均呈正相关(r=0.631~0.745,P<0.05),与CD8^(+)水平呈负相关(r=-0.701~-0.612,P<0.05)。结论:RRTI小儿血清微量元素、外周血T细胞亚群水平与正常儿童相比差异明显,说明RRTI的发生与血清微量元素及T细胞亚群有关。Objective:To analyze the correlation between serum trace element levels and immune function in children with recurrent respiratory tract infection(RRTI).Methods:120 children with RRTI were selected as the study group,while 60 healthy children who underwent physical examinations at the same time were selected as the control group.After the peripheral blood of the children in the two groups was collected uniformly,the contents of serum trace elements were measured by atomic absorption spectroscopy,and the levels of T lymphocyte subsets in peripheral blood were measured by T lymphocyte counter.The differences between the two groups were compared,and then the correlation between serum trace elements and immune function of children with RRTI was analyzed.Results:The levels of serum trace elements and peripheral blood T cell subsets in the study group were lower,while the levels of CD8^(+)were higher than those in the control group.The comparison between the two groups showed statistical significance(P<0.05).The levels of Ca,Zn,Fe,Cu,CD4^(+)and CD4^(+)/CD8^(+)were negatively correlated with pediatric RRTI(r=-0.723~-0.582,P<0.05),while CD8^(+)levels were positively correlated with pediatric RRTI(r=0.659,P<0.05).The levels of Ca,Zn,Fe,Cu were positively correlated with CD4^(+),CD4^(+)/CD8^(+)levels(r=0.631~0.745,P<0.05),and negatively correlated with CD8^(+)levels(r=-0.701~-0.612,P<0.05).Conclusion:There are significant differences in the levels of serum trace elements and peripheral blood T cell subsets between RRTI children and normal children,suggesting that the disease occurrence is related to serum trace elements and T cell subsets.

关 键 词：反复呼吸道感染 微量元素 T细胞亚群 免疫功能 

分 类 号：R725.6[医药卫生—儿科]