比伐卢定辅助PCI治疗冠心病心肌损伤的效果观察  

Effect observation of bivaludine assisted PCI treatment on improving myocardial injury in coronary heart disease

作　　者：秦丽 张海涛 QIN Li;ZHANG Haitao(Second Dept.of Cardiovascular,Pingdingshan Second People′s Hospital,Pingdingshan 467000,China)

机构地区：[1]平顶山市第二人民医院心血管内二科,河南平顶山467000

出　　处：《华夏医学》2023年第6期140-144,共5页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ202002183)。

摘　　要：目的:观察比伐卢定辅助经皮冠状动脉介入术(PCI)治疗冠心病心肌损伤的效果。方法:选取120例冠心病患者,采用数字表法将其分为观察组和对照组,每组60例。对照组采用普通肝素辅助PCI术治疗,观察组采用比伐卢定辅助PCI治疗,比较两组的凝血功能、心肌损伤标志物、心功能改善情况及治疗后的心血管不良事件(MACE)发生情况。结果:治疗后,观察组的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)均长于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)、乳酸脱氢酶(LDH)水平均低于对照组(P<0.05)。治疗后,观察组的左心室射血分数(LVEF)高于对照组,左心室舒张末期内径(LVDD)、左心室每搏量(LVSV)均少于对照组(P<0.05)。治疗后,观察组的MACE发生率为8.33%,低于对照组的20.00%(P<0.05)。结论:比伐卢定辅助PCI能有效改善冠心病患者的凝血功能,促进患者心功能恢复,并降低MACE发生风险。Objective:To observe the effect of bivaludine assisted percutaneous coronary intervention(PCI)on improving myocardial injury in patients with coronary heart disease.Methods:120 patients with coronary heart disease were selected and divided into the observation group and control group using the number table method,with 60 patients in each group.The control group were treated with ordinary heparin assisted PCI,while the observation group were treated with bivaludine assisted PCI.The coagulation function,myocardial injury markers,improvement of cardiac function,and major adverse cardiovascular events(MACE)after treatment were compared between the two groups.Results:After treatment,the activated partial thromboplastin time(APTT),prothrombin time(PT),and thrombin time(TT)of the observation group were higher than those of the control group,with a statistically significant difference(P<0.05).After treatment,the levels of creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTn I),and lactate dehydrogenase(LDH)of the observation group were lower than those of the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the observation group was higher than that of the control group,while the left ventricular end diastolic diameter(LVDD)and left ventricular stroke volume(LVSV)were lower than those of the control group(P<0.05).After treatment,the incidence of MACE in the observation group was 8.33%,lower than 20.00%in the control group(P<0.05).Conclusion:Bivaludine assisted PCI can effectively improve coagulation function,promote myocardial function,cardiac function recovery,and reduce the risk of MACE in patients with coronary heart disease.

关 键 词：冠心病 心肌损伤 比伐卢定 经皮冠状动脉介入术 心血管不良事件 

分 类 号：R543.3[医药卫生—心血管疾病]