润肺止咳汤治疗咳嗽变异性哮喘患儿的效果分析  

Therapeutic analysis of Runfei Zhike Tang on children with cough variant asthma

作　　者：刘永昌 沙广娟 高广海 翟豪强 LIU Yongchang;SHA Guangjuan;GAO Guanghai;ZHAI Haoqiang(Dept.of Pediatrics,Gushi County Maternal and Child Health Hospital,Gushi 465200;Dept.of Pediatrics,the 988th Hospital of the Joint Support Force of the People′s Liberation Army,Zhengzhou 450000,China)

机构地区：[1]固始县妇幼保健院内儿科,河南固始465200 [2]中国人民解放军联勤保障部队第九八八医院小儿科,河南郑州450000

出　　处：《华夏医学》2023年第6期145-149,共5页Acta Medicinae Sinica

摘　　要：目的:探讨润肺止咳汤治疗咳嗽变异性哮喘(CVA)患儿的效果及对血清相关因子水平、症状改善、复发率的影响。方法:选取95例CVA患儿,按照随机数字表法分为对照组47例和观察组48例。对照组采用常规西医治疗,观察组在常规西医治疗的基础上加用润肺止咳汤治疗,比较两组临床效果。结果:观察组总有效率95.83%高于对照组72.34%,差异有统计学意义(P<0.05)。观察组咳嗽消失时间及住院时间均短于对照组(P<0.05)。两组血清相关炎性因子水平均有所降低,且观察组血清白细胞介素IL-2、IL-6低于对照组(P<0.05)。两组免疫功能均得到改善,且观察组CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。两组均出现复发情况,观察组复发率2.17%低于对照组17.65%(P<0.05)。结论:润肺止咳汤治疗CVA,可减轻患儿症状,促进病情恢复,还可调节炎性因子水平,改善免疫功能,降低复发风险,疗效显著。Objective:To explore the effect of Runfei Zhike Tang on the treatment of cough variant asthma(CVA)in children and its impact on serum related factor levels,symptom improvement,and recurrence rate.Methods:95 children with CVA were selected and divided into the control group(47 cases)and observation group(48 cases)using a random number table method.The control group were treated with conventional Western medicine,while the observation group were treated with Runfei Zhike Tang on the basis of conventional Western medicine.The clinical effects of the two groups were compared.Results:The total effective rate of the observation group was 95.83%higher than that of the control group,which was 72.34%.The difference between the two groups was statistically significant(P<0.05).The cough disappearance time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).The levels of serum related inflammatory factors in both groups decreased,and the levels of interleukin-2(IL-2)and IL-6 in the observation group were lower than those in the control group(P<0.05).The immune function of both groups was improved,in addition,the CD4^(+)and CD4^(+)/CD8^(+)levels in the observation group were higher than those in the control group.CD8^(+)levels were lower than those in the control group(P<0.05).Both groups experienced recurrence,the recurrence rate was 2.17%in the observation group lower than 17.65%in the control group(P<0.05).Conclusion:Runfei Zhike Tang can alleviate symptoms in children with CVA,promote recovery,regulate levels of inflammatory factors,improve immune function,reduce the risk of recurrence,and have a significant therapeutic effect.

关 键 词：咳嗽变异性哮喘 血清炎性因子 润肺止咳汤 免疫功能 复发率 

分 类 号：R562.25[医药卫生—呼吸系统]